Deregulated NF-κB activity in haematological malignancies
Deregulated NF-κB activity in haematological malignancies
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DOI：
10.1016/j.bcp.2006.06.011
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发表时间：
2006-10-30
影响因子：
5.8
通讯作者：
Chariot, Alain
中科院分区：
文献类型：
--
作者：
Keutgens, Aurore;Robert, Isabelle;Chariot, Alain
核转录因子-kappaB家族在控制细胞增殖和凋亡中起着关键作用。结构性核因子-kappaB的激活是大多数血液系统恶性肿瘤的共同特征，因此被认为是促进这些恶性细胞增殖和存活的关键事件。在这篇综述中，我们将描述血液系统恶性肿瘤中核因子-kappa B表达下调的分子机制，并将重点介绍在该转录因子被发现20年后，该领域中仍不清楚的事情。(C)2006 Elsevier Inc.保留所有权利。
The NF-kappa B family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-kappa B activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. In this review, we will describe the molecular mechanisms underlying NF-kappa B deregulation in haematological malignancies and will highlight what is still unclear in this field, 20 years after the discovery of this transcription factor. (c) 2006 Elsevier Inc. All rights reserved.