cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.
cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.
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作者：
C. H. Charles;A. Abler;L. Lau
我们报告了 3CH134 的 cDNA 序列，这是一种立即早期基因，其转录受到血清生长因子快速而短暂的刺激。 3CH134 编码 367 个氨基酸的蛋白质，与任何已知蛋白质没有显着的序列相似性。 3CH134 可通过多种信号转导途径诱导，在成年小鼠中主要在肺中表达。使用亲和纯化的抗体，我们在血清刺激的 Balb/c 3T3 细胞中鉴定了 3CH134 蛋白，并确定其半衰期较短。
We report the cDNA sequence of 3CH134, an immediate early gene whose transcription is rapidly and transiently stimulated by serum growth factors. 3CH134 encodes a 367 amino acid protein that does not share significant sequence similarity with any known protein. 3CH134 is inducible through multiple signal transduction pathways, and in the adult mouse is expressed predominantly in the lung. Using affinity-purified antibodies, we have identified the 3CH134 protein in serum-stimulated Balb/c 3T3 cells and determined that it has a short half-life.