A Wnt signaling system that specifies two patterns of cell migration in C-elegans
A Wnt signaling system that specifies two patterns of cell migration in C-elegans
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DOI：
10.1016/s1097-2765(00)80394-9
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发表时间：
1999-11-01
期刊：
影响因子：
16
通讯作者：
Kenyon, C
中科院分区：
文献类型：
--
作者：
Whangbo, J;Kenyon, C
In C.线虫是一对双侧成神经细胞，QL和QR，产生沿沿着前后（A/P）体轴向相反方向迁移的细胞。QL及其后代向后迁移，而QR及其后代向前迁移。我们发现Wnt家族成员EGL-20以剂量依赖性方式起作用，以指定这些相反的迁移行为。高水平的EGL-20通过激活经典的Wnt信号转导通路促进后移，而低水平的EGL-20通过激活单独的未定义的通路促进前移。我们发现两个Q细胞对EGL-20的反应不同，因为它们具有不同的反应阈值。因此，在该系统中，两种不同的剂量依赖性反应不是由Wnt信号的分级水平指定的，而是由对Wnt信号传导的细胞反应性的左右不对称差异指定的。
In C. elegans, a bilateral pair of neuroblasts, QL and QR, give rise to cells that migrate in opposite directions along the anteroposterior (A/P) body axis. QL and its descendants migrate posteriorly whereas QR and its descendants migrate anteriorly. We find that a Wnt family member, EGL-20, acts in a dose-dependent manner to specify these opposite migratory behaviors. High levels of EGL-20 promote posterior migration by activating a canonical Wnt signal transduction pathway, whereas tow levels promote anterior migration by activating a separate, undefined pathway. We find that the two Q cells respond differently to EGL-20 because they have different response thresholds. Thus, in this system two distinct dose-dependent responses are specified not by graded levels of the Wnt signal, but instead by left-right asymmetrical differences in the cellular responsiveness to Wnt signaling.