Effects of exposure to hyperbaric oxygen on oxidative stress in rats with type II collagen-induced arthritis
Effects of exposure to hyperbaric oxygen on oxidative stress in rats with type II collagen-induced arthritis
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DOI：
10.1007/s10238-009-0064-y
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发表时间：
2010-03-01
影响因子：
4.6
通讯作者：
Ishihara, A.
中科院分区：
文献类型：
--
作者：
Nagatomo, F.;Gu, N.;Ishihara, A.
采用注射II型胶原诱导9周龄雌性Dark Agti大鼠关节炎模型。将暴露于1.25大气压绝对值和36%氧气浓度3周的关节炎大鼠(关节炎+高压氧组)与对照组(对照组)和未暴露于高压氧的关节炎大鼠(关节炎组)的血清氧化应激标志物活性氧代谢物(DROMs)和C反应蛋白(CRP)水平进行比较。关节炎组和关节炎+高压氧组的体重均低于对照组，而关节炎组和关节炎+高压氧组的体重差异无统计学意义。关节炎组血清DROMS和CRP水平高于对照组和关节炎+高压氧组。对照组和关节炎+高压氧组的血清CRP水平差异无统计学意义。这些结果表明，本研究中使用的高压氧暴露条件对于降低关节炎期间过度产生的活性氧水平是有效的。
Arthritis was induced in 9-week-old female Dark Agouti rats by injecting type II collagen. Serum levels of the derivatives of reactive oxygen metabolites (dROMs), which are oxidative stress markers, and C-reactive protein (CRP) in arthritic rats that were exposed to a pressure of 1.25 atmospheres absolute and an oxygen concentration of 36% for 3 weeks (arthritis + HBO group) were compared to those of control rats (control group) and arthritic rats that were not exposed to hyperbaric oxygen (arthritis group). The body weights of the arthritis and arthritis + HBO groups were lower than that of the control group, whereas no difference in the body weight was observed between the arthritis and arthritis + HBO groups. The serum levels of dROMs and CRP in the arthritis group were higher than those in the control and arthritis + HBO groups. No difference in the serum level of CRP was observed between the control and arthritis + HBO groups. These results indicate that the conditions of hyperbaric oxygen exposure used in this study are effective for reducing the levels of reactive oxygen species, which are overproduced during arthritis.