Experimental Infection of White-Tailed Deer (Odocoileus virginanus) with Heartland Virus
Experimental Infection of White-Tailed Deer (Odocoileus virginanus) with Heartland Virus
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DOI：
10.4269/ajtmh.17-0963
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发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Howerth, Elizabeth W.
中科院分区：
文献类型：
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作者：
Clarke, Lorelei L.;Ruder, Mark G.;Howerth, Elizabeth W.
中心病毒（HRTV）是一种白蛉病毒，疑似由美洲钝蜱（俗称孤星蜱）传播，据报道可引起人类疾病，其特征是血小板减少和白细胞减少。在包括白尾鹿 (WTD) 在内的多种野生动物物种中均检测到了中心病毒反应性抗体。为了更好地了解鹿在 HRTV 流行病学中的潜在作用，我们通过实验给五只 WTD 小鹿接种 HRTV，并监测其临床疾病、病毒血症、病毒脱落和血清转化。没有动物表现出临床疾病的迹象，并且接种后没有检测到病毒血症或病毒脱落。两只野生捕获的小鹿进入了研究，它们体内已经存在抗 HRTV 的抗体滴度。所有动物在针头接种后都表现出针对 HRTV 的最小免疫反应。总之，本研究并未表明 WTD 可能是自然环境中 HRTV 的储存库。
Heartland virus (HRTV) is a phlebovirus suspected to be transmitted by Amblyomma americanum, commonly known as the lone star tick, and reported to cause illness in humans, which is characterized by thrombocytopenia and leukopenia. Heartland virus-reactive antibodies have been detected in a variety of wildlife species including white-tailed deer (WTD). To better understand the potential role of deer in the epidemiology of HRTV, we experimentally inoculated five WTD fawns with HRTV and monitored for clinical disease, viremia, virus shedding, and seroconversion. None of the animals showed signs of clinical disease, and there was no detectable viremia or virus shedding post-inoculation. Two wild-caught fawns entered the study with preexisting antibody titers against HRTV. All animals showed minimal immune responses against HRTV after needle inoculation. In conclusion, this study does not indicate that WTD are a likely reservoir for HRTV in natural settings.