Acridine: a versatile heterocyclic nucleus.
Acridine: a versatile heterocyclic nucleus.
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发表时间：
2012
影响因子：
0.4
通讯作者：
Ramesh Kumar;Mandeep Kaur;M. Kumari
中科院分区：
文献类型：
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作者：
Ramesh Kumar;Mandeep Kaur;M. Kumari
吖啶是一种杂环核。它在各种药物中发挥着重要作用。许多治疗剂是基于吖啶核的，例如奎纳克林（抗疟药）、吖啶黄素和原黄素（防腐剂）、依沙吖啶（堕胎药）、安吖啶和硝曲辛（抗癌药）以及他克林。吖啶是从煤焦油的高沸点馏分中获得的。它也可以从植物和海洋中获得。吖啶经过亲核加成、亲电取代、氧化、还原、还原烷基化和光烷基化等反应。本文综述了吖啶的合成、反应、文献综述及药理学意义。
Acridine is a heterocyclic nucleus. It plays an important role in various medicines. A number of therapeutic agents are based on acridine nucleus such as quinacrine (antimalarial), acriflavine and proflavine (antiseptics), ethacridine (abortifacient), amsacrine and nitracine (anticancer), and tacrine. Acridine is obtained from high boiling fraction of coal tar. It is also obtained in nature from plant and marine sources. Acridine undergoes a number of reactions such as nucleophilic addition, electrophilic substitution, oxidation, reduction, reductive alkylation and photoalkylation. The present review article summarizes the synthesis, reaction, literature review and pharmaceutical importance of acridine.