PROSPECTIVE-STUDY OF ALCOHOL-CONSUMPTION AND RISK OF CORONARY-DISEASE IN MEN

PROSPECTIVE-STUDY OF ALCOHOL-CONSUMPTION AND RISK OF CORONARY-DISEASE IN MEN
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DOI：
10.1016/0140-6736(91)90542-w
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发表时间：
1991-08-24
期刊：
LANCET
影响因子：
168.9
通讯作者：
STAMPFER, MJ
STAMPFER, MJ
中科院分区：
医学1区
文献类型：
--
作者：
RIMM, EB;GIOVANNUCCI, EL;STAMPFER, MJ

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尽管在一些类型的研究中一直发现饮酒与冠状动脉疾病的风险呈负相关，但一些人认为，这种关联至少部分是由于不饮酒的参考组中包括了因已有疾病而戒酒的男性。对51,529名男性卫生专业人员自我报告的酒精摄入量与冠状动脉疾病之间的关系进行了前瞻性研究。1986年，参与者完成了关于食物和酒精摄入量、病史、心脏病风险因素和过去10年饮食变化的问卷调查。1988年的后续调查问卷旨在了解新诊断的冠状动脉疾病。发生冠心病确诊病例350例。调整冠状动脉危险因素后，包括饮食中胆固醇、脂肪和膳食纤维的摄入量，增加酒精摄入量与冠状动脉疾病发病率呈负相关（p < 0.001）。排除10302名目前不饮酒者或16342名可能与冠状动脉疾病（如高血压、糖尿病和痛风）相关的疾病的男性，这些疾病可能导致男性减少酒精摄入量，但对相对风险没有实质性影响。这些发现支持了饮酒与冠状动脉疾病风险之间存在因果关系的假设。
Although an inverse association between alcohol consumption and risk of coronary artery disease has been consistently found in several types of studies, some have argued that the association is due at least partly to the inclusion in the non-drinking reference group of men who abstain because of pre-existing disease. The association between self-reported alcohol intake and coronary disease was studied prospectively among 51 529 male health professionals. In 1986 the participants completed questionnaires about food and alcohol intake and medical history, heart disease risk factors, and dietary changes in the previous 10 years. Follow-up questionnaires in 1988 sought information about newly diagnosed coronary disease. 350 confirmed cases of coronary disease occurred. After adjustment for coronary risk factors, including dietary intake of cholesterol, fat, and dietary fibre, increasing alcohol intake was inversely related to coronary disease incidence (p for trend < 0.001). Exclusion of 10 302 current non-drinkers or 16 342 men with disorders potentially related to coronary disease (eg, hypertension, diabetes, and gout) which might have led men to reduce their alcohol intake, did not substantially affect the relative risks. These findings support the hypothesis that the inverse relation between alcohol consumption and risk of coronary disease is causal.