The Association between Nonalcoholic Fatty Liver Disease and CT-Measured Skeletal Muscle Mass
The Association between Nonalcoholic Fatty Liver Disease and CT-Measured Skeletal Muscle Mass
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DOI：
10.3390/jcm7100310
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发表时间：
2018-10-01
影响因子：
3.9
通讯作者：
Kim, Joo Sung
中科院分区：
文献类型：
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作者：
Choe, Eun Kyung;Kang, Hae Yeon;Kim, Joo Sung
非酒精性脂肪性肝病（NAFLD）和肌肉减少症之间的关系已被提出。本研究的目的是评估NAFLD与计算机断层扫描（CT）测量的骨骼肌质量之间的相关性。回顾性分析了到我们中心进行常规健康检查并接受腹部超声检查和腹部CT扫描的个人的临床记录。根据体重指数（BMI）调整的骨骼肌质量（CT测量的骨骼肌指数（SMICT））诊断肌肉减少症。在1828名受试者中（1121名男性;平均年龄54.9 ± 9.5岁），487名（26.6%）肥胖（BMI 25 kg/m2），454名（24.8%）肌肉质量低。无论是否肥胖，肌萎缩症受试者的NAFLD患病率均显著高于非肌萎缩症受试者（非肥胖组为35.9% vs. 26.8%，p = 0.004;肥胖组为76.6% vs. 63.0%，p = 0.003）。肌肉减少症与NAFLD的风险显著相关（调整后的比值比（OR））（95%置信区间（CI）），1.51（1.15-1.99）），NAFLD的风险随着肌肉减少症严重程度的增加而增加（校正OR（95% CI），分别为1.45（1.09-1.92）vs. 2.51（1.16-5.56），轻度vs重度肌肉减少症）。当根据SMICT四分位数分析NAFLD的风险时，最低肌肉质量四分位数与最高肌肉质量四分位数相比的校正OR和95%CI在男性中为1.78（1.17-2.72），在女性中为2.39（1.13-5.37）。通过CT精确测量的低骨骼肌质量与NAFLD独立相关，表明肌肉减少症是NAFLD的危险因素。
A relationship between nonalcoholic fatty liver disease (NAFLD) and sarcopenia has been suggested. The aim of this study was to evaluate the association between NAFLD and skeletal muscle mass measured by computed tomography (CT). The clinical records of individuals visiting our center for a routine health check-up who underwent abdominal ultrasonography and abdominal CT scanning were retrospectively reviewed. Sarcopenia was diagnosed according to body mass index (BMI)-adjusted skeletal muscle mass, which was measured by CT (CT-measured skeletal muscle index (SMICT)). Of the 1828 subjects (1121 males; mean age 54.9 +/- 9.5 years), 487 (26.6%) were obese (BMI 25 kg/m(2)), and 454 (24.8%) had low muscle mass. Sarcopenic subjects had a significantly higher prevalence of NAFLD than nonsarcopenic subjects, regardless of obesity (35.9% vs. 26.8%, p = 0.004 in the nonobese group; 76.6% vs. 63.0%, p = 0.003 in the obese group). Sarcopenia was significantly associated with the risk of NAFLD (adjusted odds ratio (OR) (95% confidence interval (CI)), 1.51 (1.15-1.99)), and the risk of NAFLD increased with increasing severity of sarcopenia (adjusted OR (95% CI), 1.45 (1.09-1.92) vs. 2.51 (1.16-5.56), mild vs. severe sarcopenia, respectively). When the risk of NAFLD was analyzed according to the SMICT quartiles, the adjusted OR and 95% CI for the lowest muscle mass quartile compared to the highest were 1.78 (1.17-2.72) in males and 2.39 (1.13-5.37) in females. Low skeletal muscle mass, which was precisely measured by CT, is independently associated with NAFLD, suggesting that sarcopenia is a risk factor for NAFLD.