Dietary restriction delays but cannot heal irradiation-induced hair graying by preserving hair follicle stem cells in quiescence.
Dietary restriction delays but cannot heal irradiation-induced hair graying by preserving hair follicle stem cells in quiescence.
复制标题
饮食限制可以延迟但不能通过保持毛囊干细胞处于静止状态来治愈辐射引起的头发变白。
作者：
Si Tao;Rongrong Qiu;Xingxing Qiu;Mingyue Su;Man Sun;Yiting Wang;Jianying Wu;Hua Wang;Duozhuang Tang
DNA损伤是干细胞老化的细胞内在原因之一，导致皮肤和血液中受损干细胞的分化诱导去除。饮食限制（DR）延缓了包括几种实验室小鼠在内的各种物种的衰老。DR是否有潜力改善DNA损伤驱动的干细胞衰竭仍不完全清楚。本研究表明，DR在γ-辐照（IR）诱导的C57BL/6J小鼠DNA损伤中显著延长了毛发变白的时间。研究表明，DR延长了毛囊的休止期。dr介导的毛囊干细胞（HFSC）休眠的延长阻断了毛发生长，并阻止了HFSC和ckit+黑色素细胞在IR下的消耗。然而，HFSC休眠的延长也与DNA修复的抑制有关，从长远来看，当头发循环在很长一段时间后重新启动时，不能防止成黑素细胞的丢失和头发变白。总之，这些结果支持一个模型，表明营养剥夺可以延迟但不能治愈DNA损伤导致的黑素母细胞灭绝，因为它使HFSCs处于长时间的静止状态，同时抑制DNA修复。切断对DR的这两种反应可能有延缓干细胞衰老的潜力。
DNA damage represents one of the cell intrinsic causes of stem cell aging, which leads to differentiation induced removal of damaged stem cells in skin and blood. Dietary restriction (DR) retards aging across various species including several strains of laboratory mice. Whether, DR has the potential to ameliorate DNA damage driven stem cell exhaustion remains incompletely understood. Here, we show that DR strongly extends the time to hair graying in response to γ-irradiation (IR) induced DNA damage of C57BL/6J mice. The study shows that DR prolongs resting phase of hair follicles. DR-mediated prolongation of hair follicle stem cell (HFSC) quiescence blocks hair growth and prevents the depletion of HFSCs and ckit+ melanoblasts in response to IR. However, prolongation of HFSC quiescence also correlates with a suppression of DNA repair and cannot prevent melanoblast loss and hair graying in the long run, when hair cycling is re-initiated even after extended periods of time. Together, these results support a model indicating that nutrient deprivation can delay but not heal DNA damage driven extinction of melanoblasts by stalling HFSCs in a prolonged state of quiescence coupled with inhibition of DNA repair. Disconnecting these two types of responses to DR could have the potential to delay stem cell aging.
影响因子：
23.9
作者：
Cerletti, Massimiliano;Jang, Young C.;Finley, Lydia W. S.;Haigis, Marcia C.;Wagers, Amy J.
通讯作者：
Wagers, Amy J.