GAP JUNCTIONAL CONDUCTANCE - COMPARISON OF SENSITIVITIES TO H-IONS AND CA-IONS

GAP JUNCTIONAL CONDUCTANCE - COMPARISON OF SENSITIVITIES TO H-IONS AND CA-IONS
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DOI：
10.1073/pnas.79.2.441
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发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
通讯作者：
BENNETT, MVL
BENNETT, MVL
中科院分区：
其他
文献类型：
--
作者：
SPRAY, DC;STERN, JH;BENNETT, MVL

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用已知H+和Ca 2+浓度的溶液灌注耦合对的Fundulus heteroclitus卵裂球之间的连接膜的一个细胞质方面。两种离子均使细胞膜电导率降低。对H+的敏感性为apprx。比Ca 2+高10,000倍。显然，连接电导可以调制的H+浓度的变化接近生理pH值，但非生理高浓度的Ca 2+，如将达到只有在细胞死亡，需要可比的变化连接电导。
One cytoplasmic aspect of the junctional membrane between coupled pairs of Fundulus heteroclitus blastomeres was perfused with solutions of known H+ and Ca2+ concentrations. Conductance of junctional membrane was decreased by either ion. The sensitivity to H+ was .apprx. 10,000 times greater than that to Ca2+. Apparently junctional conductance can be modulated by changes in H+ concentration near physiological pH but unphysiologically high concentrations of Ca2+, such as would be reached only on cell death, are required for comparable changes in junctional conductance.