Noncontact optical imaging of brain hemodynamics in preterm infants: a preliminary study.
Noncontact optical imaging of brain hemodynamics in preterm infants: a preliminary study.
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早产儿脑血流动力学的非接触式光学成像：一项初步研究
DOI：
10.1088/1361-6560/abc5a7
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发表时间：
2020-12-22
影响因子：
3.5
通讯作者：
Yu G
中科院分区：
文献类型：
--
作者：
Abu Jawdeh EG;Huang C;Mazdeyasna S;Chen L;Chen L;Bada HS;Yu G
极早产儿的血流动力学不稳定使他们处于脑损伤的高风险中。目前，在新生儿重症监护病房（NICU）中没有可靠的床旁连续监测脑血流动力学的方法。本文报告了一项可行性研究，以适应和测试一种创新的散斑对比度扩散相关断层扫描（scDCT）设备的非接触式，高密度，3D成像的早产儿脑血流（CBF）。scDCT将聚焦点近红外照明扫描到多个源位置以进行深层组织穿透，并控制具有数千像素的电子倍增电荷耦合器件相机以实现高密度采样。首先在具有已知特性的婴儿头部模拟体模中，针对已建立的漫相关光谱法对用于早产儿的优化scDCT进行评估。观察到的两个测量值之间的显著相关性验证了scDCT用于经颅脑成像的能力。然后通过比较成人前臂血流对培养箱内外测量的动脉袖带闭塞的反应，证实透明培养箱壁对scDCT测量的影响不显著。最后，scDCT设备被转移到NICU，对两名早产儿的CBF变化进行成像。没有主要器官缺陷的婴儿#1在出生后的前3周内表现出很小的CBF波动。2号婴儿在动脉导管未闭闭合药物治疗2小时后显示CBF显著增加。虽然这些CBF变化符合生理预期，但外周血氧饱和度监测未发现显著变化，这一事实表明有必要进行直接脑监测。这项技术开发及时的可行性研究是迈向更大规模临床研究的重要和必要的一步，有更多的受试者，以进一步验证其在NICU中持续监测和即时管理脑病理和干预措施。
Extremely preterm infants’ hemodynamic instability places them at high risk of brain injury. Currently there is no reliable bedside method to continuously monitor cerebral hemodynamics in the neonatal intensive care unit (NICU). This paper reports a feasibility study to adapt and test an innovative speckle contrast diffuse correlation tomography (scDCT) device for noncontact, high-density, 3D imaging of cerebral blood flow (CBF) in preterm infants. The scDCT scans a focused point near-infrared illumination to multiple source positions for deep tissue penetration, and controls an electron multiplying charge-coupled-device camera with thousands of pixels to achieve a high-density sampling. The optimized scDCT for use in preterm infants was first evaluated against an established diffuse correlation spectroscopy in an infant-head-simulating phantom with known properties. The observed significant correlation between the two measurements verified the capability of scDCT for transcranial brain imaging. The insignificant influence of transparent incubator wall on scDCT measurements was then confirmed by comparing adult forearm blood flow responses to artery cuff occlusions measured inside and outside the incubator. Finally, the scDCT device was moved to the NICU to image CBF variations in two preterm infants. Infant #1 with no major organ deficits showed little CBF fluctuation over the first 3 weeks of life. Infant #2 showed a significant CBF increase after the 2-hour pharmacotherapy for patent ductus arteriosus closure. While these CBF variations meet physiological expectations, the fact that no significant changes are noted with peripheral monitoring of blood oxygen saturation suggests necessity of direct cerebral monitoring. This feasibility study with timely technology development is an important and necessary step towards larger clinical studies with more subjects to further validate it for continuous monitoring and instant management of cerebral pathologies and interventions in the NICU.
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DOI：
10.1136/bmj.g7635
发表时间：
2015-01-05
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Hyttel-Sorensen S;Pellicer A;Alderliesten T;Austin T;van Bel F;Benders M;Claris O;Dempsey E;Franz AR;Fumagalli M;Gluud C;Grevstad B;Hagmann C;Lemmers P;van Oeveren W;Pichler G;Plomgaard AM;Riera J;Sanchez L;Winkel P;Wolf M;Greisen G
通讯作者：
Greisen G
影响因子：
5.7
作者：
Cheng, Ran;Shang, Yu;Yu, Guoqiang
通讯作者：
Yu, Guoqiang
DOI：
10.1364/josaa.14.000192
发表时间：
1997-01-01
影响因子：
1.9
作者：
Boas, DA;Yodh, AG
通讯作者：
Yodh, AG
影响因子：
3.6
作者：
Chock, Valerie Y.;Rose, Laura A.;Punn, Rajesh
通讯作者：
Punn, Rajesh
影响因子：
5.3
作者：
Boas, David A.;Sakadzic, Sava;Carp, Stefan A.
通讯作者：
Carp, Stefan A.