Session III: Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Inflammatory, Oxidative, and Metabolic Processes
Session III: Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Inflammatory, Oxidative, and Metabolic Processes
复制标题
DOI：
10.1093/gerona/gls112
复制
发表时间：
2012-07-01
影响因子：
5.1
通讯作者：
Yaffe, Kristine
中科院分区：
文献类型：
--
作者：
Craft, Suzanne;Foster, Thomas C.;Yaffe, Kristine
来自基础科学和人类流行病学研究的越来越多的证据表明，炎症、氧化应激和代谢异常与年龄相关的认知能力下降和损害有关。本文总结了在第二届认知老龄化峰会上提出的关于这些主题的精选研究。在这一会议上，发言者提出了证据，强调了这些过程和途径在年龄相关性认知下降中的作用，并指出了对非痴呆老年人进行干预的可能目标。讨论的具体领域包括损伤或感染后细胞因子产生的年龄差异，氧化应激导致记忆巩固变化的潜在机制，胰岛素对大脑信号和记忆的影响，以及代谢综合征和老年人认知能力下降之间的关联。这些演讲强调了我们对与年龄相关的认知衰退的机制和修饰物的理解方面的进展，并提供了对促进老年人认知健康的潜在目标的见解。
There is increasing evidence from basic science and human epidemiological studies that inflammation, oxidative stress, and metabolic abnormalities are associated with age-related cognitive decline and impairment. This article summarizes selected research on these topics presented at the Cognitive Aging Summit II. Speakers in this session presented evidence highlighting the roles of these processes and pathways on age-related cognitive decline, pointing to possible targets for intervention in nondemented older adults. Specific areas discussed included age differences in the production of cytokines following injury or infection, mechanisms underlying oxidative stress-induced changes in memory consolidation, insulin effects on brain signaling and memory, and the association between metabolic syndrome and cognitive decline in older adults. These presentations emphasize advances in our understanding of mechanisms and modifiers of age-related cognitive decline and provide insights into potential targets to promote cognitive health in older adults.