Differentiation of T-cell precursors in nude mice demonstrated by immunofluorescence of T-cell membrane markers.
Differentiation of T-cell precursors in nude mice demonstrated by immunofluorescence of T-cell membrane markers.
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DOI：
10.1084/jem.138.5.1044
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发表时间：
1973-11-01
期刊：
影响因子：
--
通讯作者：
Kindred B
中科院分区：
文献类型：
--
作者：
Loor F;Kindred B
当来自AKR小鼠（TL-，θ-AKR）的胸腺移植到BALB/c-nu/nu小鼠（TL 2，θ-C3 H）时，移植的胸腺迅速被宿主淋巴细胞重新填充，即，具有TL 2和θ-C3 H T淋巴细胞膜抗原标志物的淋巴细胞。θ-C3 H淋巴细胞也迅速出现在脾和淋巴结中。几周后，根据胸腺、脾脏或淋巴结中TL阳性胸腺细胞或θ-C3 H阳性淋巴细胞的数量，无法区分移植AKR胸腺的BALB/c裸鼠和正常BALB/c小鼠。这些实验提供了明确的证据，前体细胞的存在T区室的淋巴系统在裸鼠。他们强烈建议宿主来源的T细胞参与移植同种异体胸腺的裸鼠的一些T细胞功能的恢复。
When the thymus from an AKR mouse (TL-, θ-AKR) is grafted to a BALB/c-nu/nu mouse (TL2, θ-C3H), the grafted thymus is rapidly repopulated by host lymphocytes, i.e., lymphocytes having the TL2 and θ-C3H T-lymphocyte membrane antigen markers. θ-C3H lymphocytes also appear rapidly in the spleen and lymph nodes. After a few weeks, BALB/c nude mice grafted with AKR thymus and normal BALB/c mice could not be distinguished on the basis of the number of TL-positive thymocytes or θ-C3H-positive lymphocytes in thymus, spleen, or lymph nodes. These experiments give a definitive proof of the existence of precursor cells for the T compartment of the lymphoid system in the nude mouse. They strongly suggest the involvement of host-derived T cells in the recovery of some T-cell functions by nude mice grafted with allogeneic thymuses.