Duration of QRS Complex in Resting Electrocardiogram Is a Predictor of Sudden Cardiac Death in Men
Duration of QRS Complex in Resting Electrocardiogram Is a Predictor of Sudden Cardiac Death in Men
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DOI：
10.1161/circulationaha.111.025577
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发表时间：
2012-05-29
期刊：
影响因子：
37.8
通讯作者：
Laukkanen, Jari A.
中科院分区：
文献类型：
--
作者：
Kurl, Sudhir;Makikallio, Timo H.;Laukkanen, Jari A.
背景-先前的研究表明，心电图中QRS持续时间的增加与全因死亡的风险有关。然而，QRS时限与心源性猝死（SCD）风险的相关性在大规模人群研究中尚未得到充分证实。我们的目的是研究QRS波持续时间与SCD在一个以人口为基础的样本的mans.Methods和结果的关系，这项前瞻性研究是基于一个队列的2049名男性年龄在42至60岁的基线与19年的随访，在此期间，共发生156个SCD。作为一个连续变量，QRS时限每增加10 ms，SCD的风险增加27%（相对风险，1.27; 95%可信区间，1.14-1.40; P < 0.001）。与QRS持续时间>110 ms（最高五分位数）的受试者相比，QRS持续时间>110 ms（最高五分位数）的受试者发生SCD的风险为2.50倍（相对风险，2.50; 95%置信区间，1.38-4.55; P = 0.002）。
Background-Previous studies indicate that increased QRS duration in ECG is related to the risk of all-cause death. However, the association of QRS duration with the risk of sudden cardiac death (SCD) is not well documented in large population-based studies. Our aim was to examine the relation of QRS duration with SCD in a population-based sample of men.Methods and Results-This prospective study was based on a cohort of 2049 men aged 42 to 60 years at baseline with a 19-year follow-up, during which a total of 156 SCDs occurred. As a continuous variable, each 10-ms increase in QRS duration was associated with a 27% higher risk for SCD (relative risk, 1.27; 95% confidence interval, 1.14-1.40; P < 0.001). Subjects with QRS duration of >110 ms (highest quintile) had a 2.50-fold risk for SCD (relative risk, 2.50; 95% confidence interval, 1.38-4.55; P = 0.002) compared with those with QRS duration of