EFFECT OF EXCESS DIETARY GLUCOSE ON GROWTH AND IMMUNE-RESPONSE OF MANDUCA-SEXTA
EFFECT OF EXCESS DIETARY GLUCOSE ON GROWTH AND IMMUNE-RESPONSE OF MANDUCA-SEXTA
复制标题
DOI：
10.1016/0022-1910(92)90078-r
复制
发表时间：
1992-07-01
影响因子：
2.2
通讯作者：
SPENCE, KD
中科院分区：
文献类型：
--
作者：
BEDOYAN, JK;PATIL, CS;SPENCE, KD
将细菌注射到 M. sexta 幼虫的血腔中后，血淋巴葡萄糖水平迅速下降。葡萄糖水平的下降似乎主要是由于幼虫暂时停止进食，而不是新陈代谢的改变。为了破坏葡萄糖凝集素、scolexin（以前称为 M13）的活性，通过在含有过量葡萄糖或含葡萄糖的二糖、蔗糖的饮食中进行培养来增加血淋巴葡萄糖水平。尽管饮食中葡萄糖的增加似乎不会影响五龄幼虫的存活，但在不注射或注射后，它们的发育会减慢。此外，过量的蔗糖或葡萄糖饮食（而不是过量的果糖饮食）会导致更大的改良形式的 scolexin 的合成。讨论了 scolexin 改变的可能性质及其对该蛋白质活性的可能影响。
The injection of bacteria into the haemocoel of M. sexta larvae is followed by a rapid drop in haemolymph glucose levels. The fall in glucose levels appears to be primarily due to a temporary cessation of feeding by larvae rather than an alteration in metabolism. In an attempt to compromise the activity of the glucose-lectin, scolexin (earlier termed M13), the haemolymph glucose levels were increased by culture on a diet containing an excess of either glucose or the glucose-containing disaccharide, sucrose. Although an increase in glucose in the diet did not appear to influence survival of the fifth-instar larvae, without or following injection, their development was slowed. Further, either excess sucrose or glucose diets but not the excess fructose diet led to the synthesis of a larger, modified form of scolexin. The possible nature of the alteration in scolexin, as well as its possible effect on the activity of this protein are discussed.