No mutations found in candidate genes for dystocia
No mutations found in candidate genes for dystocia
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DOI：
10.1093/humrep/14.10.2451
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发表时间：
1999-10-01
影响因子：
6.1
通讯作者：
Nordenskjöld, A
中科院分区：
文献类型：
--
作者：
Algovik, M;Lagercrantz, J;Nordenskjöld, A
难产是一种以产程延长或功能障碍为特征的疾病。晚分娩或根本不分娩会增加剖腹产、婴儿发病率和死亡率的风险。难产的家族聚集性提示多基因背景。我们研究了三个难产的候选基因，即睾酮5-α还原酶1型基因、前列腺素F2 α受体基因和内皮素1基因，并对23例难产妇女进行了突变筛查，其中12例影响了亲属，未发现突变，因此这些基因中的任何一个都不太可能是男性难产的主要原因。
Dystocia is a disorder characterized by prolonged or dysfunctional labour. Delivery that starts late or not at all, leads to an increased risk for Caesarean section, infant morbidity and mortality. Familial aggregations of dystocia suggest a polygenic background. We have studied three candidate genes for dystocia, i.e. the genes for testosterone 5-alpha reductase type 1, prostaglandin F2 alpha receptor and endothelin 1 and performed mutational screening in 23 women with dystocia, of which 12 have affected relatives, No mutations were found, making it unlikely that any of these genes represent a major cause of dystocia in man.