Claudin‐1 immunohistochemistry for distinguishing malignant from benign epithelial lesions of prostate

Claudin‐1 immunohistochemistry for distinguishing malignant from benign epithelial lesions of prostate
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Claudin-1免疫组化用于区分前列腺良恶性上皮病变

DOI:
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发表时间:
2007
期刊:
The Prostate
影响因子:
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通讯作者:
S. Krajewski
S. Krajewski
中科院分区:
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文献类型:
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作者:
M. Krajewska;Allen H Olson;D. Mercola;John Calvin Reed;S. Krajewski

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紧密连接蛋白是一个由大约23种完整的膜紧密连接(TJ)蛋白组成的家族,其在上皮和内皮细胞中维持细胞极性和细胞旁屏障功能。虽然Claudin-1在各种癌症中被证明是典型的下调,但这种蛋白在正常和肿瘤组织中的精确表达模式仍然很难表征。
Claudins are a family of approximately 23 integral membrane tight junction (TJ) proteins that maintain cell polarity and paracellular barrier functions in epithelial and endothelial cells. Although Claudin‐1 was demonstrated to be typically downregulated in various cancers, the precise expression patterns of this protein in normal and neoplastic tissues remain poorly characterized.
DOI: 10.1073/pnas.96.10.5752
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