Peripheral blood leukocyte expression level of IncRNA steroid receptor RNA activator (SRA) and its association with polycystic ovary syndrome: a case control study
Peripheral blood leukocyte expression level of IncRNA steroid receptor RNA activator (SRA) and its association with polycystic ovary syndrome: a case control study
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外周血白细胞lncRNA类固醇受体RNA激活剂（SRA）表达水平及其与多囊卵巢综合征的关联：病例对照研究
DOI：
10.3109/09513590.2014.999763
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发表时间：
2015-05-01
影响因子：
2
通讯作者：
Qu, Qinglan
中科院分区：
文献类型：
--
作者：
Liu, Zhenteng;Hao, Cuifang;Qu, Qinglan
多囊卵巢综合征（PCOS）是一种常见的生殖内分泌疾病。长链非编码RNA（IncRNA）类固醇受体RNA激活因子（SRA）影响多种生物学过程。然而，尚不清楚IncRNA SRA是否与PCOS相关。本研究检测了PCOS患者IncRNA SRA的表达水平，并分析了IncRNA SRA与PCOS多个关键内分泌指标的相关性。LncRNA SRA在PCOS组的表达明显高于对照组。PCOS组IncRNA SRA表达与BMI呈正相关。此外，肥胖与PCOS妇女IncRNA SRA的高表达呈正相关，但在对照组妇女中无相关性。总之，我们发现IncRNA SRA的表达与PCOS有潜在的相关性，并且与PCOS患者的肥胖呈正相关，从而提示IncRNA SRA的升高可能是PCOS易感个体肥胖相关过程中的一个重要介质。
Polycystic ovary syndrome (PCOS) has been recognized as a common reproductive and endocrine disorder. Long noncoding RNA (IncRNA) steroid receptor RNA activator (SRA) affects multiple biological processes. However, it is not known whether IncRNA SRA is associated with PCOS. In the study, we measured the expression level of IncRNA SRA in PCOS patients, and analyzed the association between IncRNA SRA and multiple key endocrine parameters of PCOS. LncRNA SRA expression was significantly higher in the women with PCOS than that in the controls. There was a significant positive correlation between IncRNA SRA expression and BMI in PCOS group. Furthermore, obesity positively associates with the high expression of IncRNA SRA in PCOS women but without the association in control women. In conclusion, we found that the IncRNA SRA expression is potentially associated with PCOS and it has positive correlation with obesity in PCOS, thereby suggesting that elevated IncRNA SRA might be an important mediator in adiposity-related processes in PCOS for susceptible individuals.