Effect of wheat bran on glycemic control and risk factors for cardiovascular disease in type 2 diabetes
Effect of wheat bran on glycemic control and risk factors for cardiovascular disease in type 2 diabetes
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DOI：
10.2337/diacare.25.9.1522
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发表时间：
2002-09-01
期刊：
影响因子：
16.2
通讯作者：
Josse, RG
中科院分区：
文献类型：
--
作者：
Jenkins, DJA;Kendall, CWC;Josse, RG
目的-队列研究表明，谷物纤维降低糖尿病和冠心病（CHD）的风险。因此，我们评估了麦麸对2型diabetes.Research设计和方法的血糖控制和冠心病危险因素的影响-共23例2型糖尿病（16名男性和7名绝经后女性）完成了两个3个月的随机交叉研究。在测试阶段，面包和早餐谷物作为谷物纤维含量高的产品（19 g/天额外的谷物纤维）提供。在控制阶段，补充低纤维（4克/天额外的谷物纤维）。结果-之间的测试和对照治疗，没有差异，体重，空腹血糖，HbA（1C），血脂，载脂蛋白，血压，血尿酸，凝血因子，同型半胱氨酸，C-反应蛋白，镁，钙，铁，或铁蛋白。实验期LDL氧化水平明显高于对照期（12.1 ± 5.4%，P < 0.034）。最初招募的受试者，更多的退出研究的健康和食物偏好的原因，从控制阶段（16名受试者）比测试phase（11名受试者）。可能需要更长的研究来证明谷物纤维的好处。或者，饮食中的谷物纤维可能是全谷物的另一种成分的标志，它赋予健康优势或健康的生活方式。
OBJECTIVE- Cohort studies indicate that cereal fiber reduces the risk of diabetes and coronary heart disease (CHD). Therefore, we assessed the effect of wheat bran on glycemic control and CHD risk factors in type 2 diabetes.RESEARCH DESIGN AND METHODS- A total of 23 subjects with type 2 diabetes (16 men and 7 postmenopausal women) completed two 3-month phases of a randomized crossover study. In the test phase, bread and breakfast cereals were provided as products high in cereal fiber (19 g/day additional cereal fiber). In the control phase, supplements were low in fiber (4 g/day additional cereal fiber).RESULTS- Between the test and control treatments, no differences were seen in body weight, fasting blood glucose, HbA(1c), serum lipids, apolipoproteins, blood pressure, serum uric acid, clotting factors, homocysteine, C-reactive protein, magnesium, calcium, iron, or ferritin. LDL oxidation in the test phase was higher than that seen in the control phase (12.1 5.4%, P < 0.034). Of the subjects originally recruited, more dropped out of the study for health and food preference reasons from the control phase (16 subjects) than the test phase (11 subjects).CONCLUSIONS- High-fiber cereal foods did not improve conventional markers of glycemic control or risk factors for CHD in type 2 diabetes over 3 months. Possibly longer studies are required to demonstrate the benefits of cereal fiber. Alternatively, cereal fiber in the diet may be a marker for another component of whole grains that imparts health advantages or a healthy lifestyle.