Dynamic estimation of the myocardial oxygen extraction ratio during dipyridamole stress by MRI: A preliminary study in canines
Dynamic estimation of the myocardial oxygen extraction ratio during dipyridamole stress by MRI: A preliminary study in canines
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DOI：
10.1002/mrm.20025
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发表时间：
2004-04-01
影响因子：
3.3
通讯作者：
Woodard, PK
中科院分区：
文献类型：
--
作者：
Zheng, J;Wang, JH;Woodard, PK
心肌氧提取分数（OEF）反映了心肌供氧量和需氧量之间的平衡。在犬的药理学血管舒张过程中，MRI证实了心肌OEF定量的可行性。静脉滴注双嘧达莫可增加血流量，改变心肌氧含量。在双嘧达莫诱导的血管舒张术中取动脉和冠状窦血，测定心肌血氧含量。在血管舒张过程中动态测量心肌T-2，并采用简化扩散模型作为心肌OEF和血容量的函数进行量化。结果显示MRI测得的心肌OEF值与采血测得的心肌OEF值有很强的相关性（R-2 = 0.89）。通过直接向犬冠状动脉注射双嘧达莫证实了OEF的区域差异。结合血管扩张剂应激，OEF的动态评估可以提供假定的心肌血流储备测量，并允许连续监测心肌剂量和反应。中国医学杂志，2004,31(5):718-726。(C) 2004 Wiley-Liss, Inc。
The myocardial oxygen extraction fraction (OEF) reflects the balance between myocardial oxygen supply and demand. The feasibility of quantifying myocardial OEF was demonstrated with MRI during pharmacologic vasodilation in dogs. Dipyridamole was infused intravenously to increase blood flow and change in myocardial oxygen content. Arterial and coronary sinus blood sampling was performed during dipyridamole-induced vasodilation to measure the myocardial blood oxygen content. Myocardial T-2 was measured dynamically during the vasodilation, and quantified with a simplified diffusion model as a function of myocardial OEF and blood volume. The results showed a strong correlation (R-2 = 0.89) between myocardial OEF values measured by MRI and those measured by blood sampling. Regional differences in the OEF were demonstrated by direct infusion of dipyridamole into coronary arteries in dogs. Combined with vasodilator stress, dynamic assessments of the OEF may provide a putative measurement of myocardial flow reserve and allow consecutive monitoring of myocardial dose and response. Magn Reson Med 51:718-726, 2004. (C) 2004 Wiley-Liss, Inc.