Extra-respiratory manifestations of COVID-19
Extra-respiratory manifestations of COVID-19
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DOI：
10.1016/j.ijantimicag.2020.106024
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发表时间：
2020-08-01
影响因子：
10.8
通讯作者：
Hsueh, Po-Ren
中科院分区：
文献类型：
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作者：
Lai, Chih-Cheng;Ko, Wen-Chien;Hsueh, Po-Ren
由严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）已成为全球健康威胁。虽然大多数COVID-19患者表现为发热和呼吸道症状，但SARS-CoV-2感染也可能累及其他器官/系统，并出现呼吸道外表现，包括心脏、胃肠道、肝脏、肾脏、神经系统、嗅觉、味觉、眼部、皮肤和血液学症状。偶尔，这些呼吸道外症状/体征代表SARS-CoV-2感染的初始表现，在发热或呼吸道表现之前。因此，对COVID-19呼吸道外表现的全面综述旨在帮助临床医生更好地了解与SARS-CoV-2感染相关的临床表现范围，从而在鉴别诊断中考虑COVID-19。当患者出现这些呼吸道外表现时，应进行SARS-CoV-2筛查试验。此外，临床医生应警惕抗SARS-CoV-2药物的不良反应，这些药物可模拟COVID-19的呼吸道外表现。此外，一些呼吸道外的表现，如眼睛和胃肠道受累，可能是由SARS-CoV-2的直接入侵引起的。因此，在管理相关临床标本时应采取保护措施。最后，一些呼吸道外表现，如心脏受累、急性肾损伤、凝血功能障碍和血栓并发症，可能与预后不良有关。(C)2020 Elsevier B. V.和国际化疗学会。All rights reserved.
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global health threat. Although most patients with COVID-19 manifest fever and respiratory tract symptoms, SARS-CoV-2 infection may also involve other organs/systems and present with extra-respiratory manifestations, including cardiac, gastrointestinal, hepatic, renal, neurological, ol-factory, gustatory, ocular, cutaneous and haematological symptoms. Occasionally, these extra-respiratory symptoms/signs represent the initial presentation of SARS-CoV-2 infection, prior to fever or respiratory manifestations. Therefore, this comprehensive review of the extra-respiratory manifestations of COVID-19 is intended to help clinicians better understand the range of clinical presentations associated with SARS-CoV-2 infection, allowing the consideration of COVID-19 in differential diagnoses. A screening test for SARS-CoV-2 should be performed when patients have these extra-respiratory manifestations. In addition, clinicians should be alerted to the adverse effects of anti-SARS-CoV-2 agents that can mimic the extra -respiratory manifestations of COVID-19. Moreover, some extra-respiratory manifestations, such as ocular and gastrointestinal involvement, may be caused by direct invasion of SARS-CoV-2. Therefore, protec-tive measures should be taken while managing the associated clinical specimens. Finally, several extra-respiratory manifestations, such as cardiac involvement, acute kidney injury, coagulation disorders and thrombotic complications, could be associated with a poor prognosis. (C) 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.