Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
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DOI：
10.1038/nm.2472
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发表时间：
2011-10-01
期刊：
影响因子：
82.9
通讯作者：
Ntziachristos, Vasilis
中科院分区：
文献类型：
--
作者：
van Dam, Gooitzen M.;Themelis, George;Ntziachristos, Vasilis
晚期卵巢癌的预后仍然很差。肿瘤特异性术中荧光成像可以改善细胞减灭术中的分期和减瘤工作，从而改善预后。 90-95% 的上皮性卵巢癌中叶酸受体-α (FR-α) 过度表达，促使人们研究使用 FR-α 靶向荧光剂在卵巢癌手术中进行术中肿瘤特异性荧光成像。在卵巢癌患者中，使用 FR-α 靶向荧光剂进行术中肿瘤特异性荧光成像，展示了在卵巢癌患者中改善术中分期和更彻底的细胞减灭术的潜在应用。
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-alpha (FR-alpha) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-alpha-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-alpha-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.