Voxel-based analysis of multiple-system atrophy of cerebellar type:: complementary results by combining voxel-based morphometry and voxel-based relaxometry
Voxel-based analysis of multiple-system atrophy of cerebellar type:: complementary results by combining voxel-based morphometry and voxel-based relaxometry
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DOI：
10.1016/j.neuroimage.2004.11.022
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发表时间：
2005-03-01
期刊：
影响因子：
5.7
通讯作者：
Klockgether, T
中科院分区：
文献类型：
--
作者：
Specht, K;Minnerop, M;Klockgether, T
基于体素的弛豫测量 (VBR) 是一种新颖的形态测量方法，可逐个体素地分析从多回波 T2 加权图像得出的弛豫率 R2。我们使用 VBR 研究了 14 名患有小脑型多系统萎缩 (MSA-C) 患者的大脑形态，并将结果与 T1 加权图像基于体素的形态测量 (VBM) 获得的结果进行了比较。 VBR 分析显示小脑和脑干舒张率 R2 降低，反映幕下脑萎缩。受影响的区域很大程度上对应于 VBM 显示灰质和白质减少的区域。此外，壳核中的 R2 增加，而 VBM 未显示异常的区域。我们的数据表明，VBR 和 VBM 的结合提供了有关 MSA-C 大脑形态的收敛和互补信息。 (C) 2004 Elsevier Inc. 保留所有权利。
Voxel-based relaxometry (VBR) is a novel morphometric method that analyses the relaxation rate R2 derived from multi-echo T2-weighted images on a voxel-by-voxel basis. We used VBR to study the brain morphology of 14 patients suffering from multiple-system atrophy of cerebellar type (MSA-C) and compared the results with those obtained by voxel-based morphometry (VBM) of T1-weighted images. VBR analysis revealed reduction of relaxation rate R2 in the cerebellum and brainstem reflecting infratentorial brain atrophy. The affected regions largely corresponded to those regions in which VBM showed reductions of grey and white matter. In addition, R2 was increased in the putamen, a region in which VBM did not show abnormalities. Our data show that the combination of VBR and VBM provided convergent and complimentary information about the brain morphology of MSA-C. (C) 2004 Elsevier Inc. All rights reserved.