Post-Discharge Health Status and Symptoms in Patients with Severe COVID-19.
Post-Discharge Health Status and Symptoms in Patients with Severe COVID-19.
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DOI：
10.1007/s11606-020-06338-4
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发表时间：
2021-03
影响因子：
5.7
通讯作者：
Horwitz LI
中科院分区：
文献类型：
--
作者：
Weerahandi H;Hochman KA;Simon E;Blaum C;Chodosh J;Duan E;Garry K;Kahan T;Karmen-Tuohy SL;Karpel HC;Mendoza F;Prete AM;Quintana L;Rutishauser J;Santos Martinez L;Shah K;Sharma S;Simon E;Stirniman AZ;Horwitz LI
对于严重的 COVID-19 疾病的长期恢复知之甚少。在这里，我们描述了重症 COVID-19 患者出院 1 个月后的整体健康状况、身体健康状况和心理健康状况。这是一项前瞻性单一卫生系统观察性队列研究，研究对象为因实验室确诊的 COVID-19 疾病而住院 18 年以上的患者，这些患者在入院期间至少需要 6 升氧气，具有完整的基线认知和功能状态，并活着出院。参与者在出院后 30 至 40 天内入组。结果是通过经过验证的调查工具得出的：PROMIS® 呼吸困难特征和 PROMIS® Global Health-10。共有 161 名患者（符合资格的 40.6%）入组； 152 人（38.3%）完成了调查。中位年龄为 62 岁（四分位距 [IQR]，50–67）； 57 名（37%）为女性。总体而言，113/152 (74%) 名参与者在前一周内报告呼吸急促（中位数为 3 分（满分 10 分 [IQR 0–5]）），而 COVID-19 感染前的参与者为 47/152 (31%) (0，IQR 0–1)，p < 0.001。参与者还认为，与新冠疫情前的状态相比，新冠疫情后的身体健康状况和心理健康状况更差（43.8，标准差 9.3；心理健康状况 47.3，标准差 9.3）（分别为 54.3，标准差 9.3；54.3，标准差 7.8），均 p< 0.001。美国普通人口的身心健康平均值为 50 (SD 10)。共有 52/148 (35.1%) 名在新冠疫情前没有氧气需求的患者出院后需要家庭氧气； 20/148 (13.5%) 表示在调查时仍在使用氧气。患有严重 COVID-19 疾病的患者通常会在出院后至少几周内出现影响其呼吸状况、身体健康和心理健康的后遗症。在线版本包含可在 10.1007/s11606-020-06338-4 获取的补充材料。
Little is known about long-term recovery from severe COVID-19 disease. Here, we characterize overall health, physical health, and mental health of patients 1 month after discharge for severe COVID-19. This was a prospective single health system observational cohort study of patients ≥ 18 years hospitalized with laboratory-confirmed COVID-19 disease who required at least 6 l of oxygen during admission, had intact baseline cognitive and functional status, and were discharged alive. Participants were enrolled between 30 and 40 days after discharge. Outcomes were elicited through validated survey instruments: the PROMIS® Dyspnea Characteristics and PROMIS® Global Health-10. A total of 161 patients (40.6% of eligible) were enrolled; 152 (38.3%) completed the survey. Median age was 62 years (interquartile range [IQR], 50–67); 57 (37%) were female. Overall, 113/152 (74%) participants reported shortness of breath within the prior week (median score 3 out of 10 [IQR 0–5]), vs 47/152 (31%) pre-COVID-19 infection (0, IQR 0–1), p < 0.001. Participants also rated their physical health and mental health as worse in their post-COVID state (43.8, standard deviation 9.3; mental health 47.3, SD 9.3) compared to their pre-COVID state, (54.3, SD 9.3; 54.3, SD 7.8, respectively), both p < 0.001. Physical and mental health means in the general US population are 50 (SD 10). A total of 52/148 (35.1%) patients without pre-COVID oxygen requirements needed home oxygen after hospital discharge; 20/148 (13.5%) reported still using oxygen at time of survey. Patients with severe COVID-19 disease typically experience sequelae affecting their respiratory status, physical health, and mental health for at least several weeks after hospital discharge. The online version contains supplementary material available at 10.1007/s11606-020-06338-4.
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DOI：
10.1001/jama.2020.6775
发表时间：
2020-01-01
期刊：
JAMA, Journal of the American Medical Association
影响因子：
--
作者：
Richardson, Safiya;Hirsch, Jamie S.;,
通讯作者：
,
影响因子：
7.5
作者：
Klok, F. A.;Kruip, M. J. H. A.;Endeman, H.
通讯作者：
Endeman, H.
影响因子：
158.5
作者：
Herridge, Margaret S.;Tansey, Catherine M.;Cheung, Angela M.
通讯作者：
Cheung, Angela M.
影响因子：
--
作者：
Griffiths, RD;Jones, C
通讯作者：
Jones, C
影响因子：
10
作者：
Kamdar, Biren B.;Suri, Rajat;Hopkins, Ramona O.
通讯作者：
Hopkins, Ramona O.