Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine.
Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine.
复制标题
DOI：
10.2147/dddt.s44401
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Yuan W
中科院分区：
文献类型：
--
作者：
Hong X;Wei L;Wu F;Wu Z;Chen L;Liu Z;Yuan W
几十年前，针头首次被概念化用于药物递送，在一定程度上克服了皮下注射针头和常规透皮药物递送系统的缺点并保留了其优点。溶解和可生物降解的微针技术已用于不同药物和疫苗的经皮持续递送。本文介绍了微针的几何形状和代表性的溶解和可生物降解的微针通过皮肤的方法，其次是制造方法。最后，本文提出了一些需要进一步研究的观点。
Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. This review describes microneedle geometry and the representative dissolving and biodegradable microneedle delivery methods via the skin, followed by the fabricating methods. Finally, this review puts forward some perspectives that require further investigation.