Stress inoculation modeled in mice.
Stress inoculation modeled in mice.
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DOI：
10.1038/tp.2015.34
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发表时间：
2015-03-31
影响因子：
6.8
通讯作者：
Lyons DM
中科院分区：
文献类型：
--
作者：
Brockhurst J;Cheleuitte-Nieves C;Buckmaster CL;Schatzberg AF;Lyons DM
压力接种需要间歇性地暴露于轻度压力的情况下，在暴露心理疗法和复原力训练的背景下提供学习、实践和改善应对的机会。在这里，我们调查行为和激素方面的压力接种模型小鼠。随机分配至应激接种或对照处理条件的小鼠在旷场、物体探索和悬尾试验期间评估皮质酮应激激素反应和行为。应激接种训练课程，急性增加血浆皮质酮水平减少随后的不动作为衡量行为绝望的尾巴悬挂测试。应力接种也减少了随后的冻结在开放领域，尽管相当水平的趋触性小鼠从两个治疗条件。压力接种随后减少新的对象探索lavelets和减少皮质酮的反应，反复约束。这些结果表明，应激接种急性刺激糖皮质激素信号，然后增强小鼠主动应对行为的后续指示。与筛选不存在易受压力影响或存在弹性个体特征的小鼠模型不同，压力接种训练反映了一种依赖于经验的学习过程，类似于旨在建立人类弹性的干预措施。应激接种的小鼠模型可能为人类精神疾病的新预防策略或治疗提供新的见解，这些疾病是由应激性生活事件引发和加剧的。
Stress inoculation entails intermittent exposure to mildly stressful situations that present opportunities to learn, practice and improve coping in the context of exposure psychotherapies and resiliency training. Here we investigate behavioral and hormonal aspects of stress inoculation modeled in mice. Mice randomized to stress inoculation or a control treatment condition were assessed for corticosterone stress hormone responses and behavior during open-field, object-exploration and tail-suspension tests. Stress inoculation training sessions that acutely increased plasma levels of corticosterone diminished subsequent immobility as a measure of behavioral despair on tail-suspension tests. Stress inoculation also decreased subsequent freezing in the open field despite comparable levels of thigmotaxis in mice from both treatment conditions. Stress inoculation subsequently decreased novel-object exploration latencies and reduced corticosterone responses to repeated restraint. These results demonstrate that stress inoculation acutely stimulates glucocorticoid signaling and then enhances subsequent indications of active coping behavior in mice. Unlike mouse models that screen for the absence of vulnerability to stress or presence of traits that occur in resilient individuals, stress inoculation training reflects an experience-dependent learning-like process that resembles interventions designed to build resilience in humans. Mouse models of stress inoculation may provide novel insights for new preventive strategies or therapeutic treatments of human psychiatric disorders that are triggered and exacerbated by stressful life events.
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影响因子：
2.1
作者：
Meichenbaum, D;Novaco, R
通讯作者：
Novaco, R
影响因子：
11
作者：
Anacker, C.;Zunszain, P. A.;Cattaneo, A.;Carvalho, L. A.;Garabedian, M. J.;Thuret, S.;Price, J.;Pariante, C. M.
通讯作者：
Pariante, C. M.
影响因子：
25.8
作者：
Nestler, Eric J.
通讯作者：
Nestler, Eric J.
影响因子：
12.8
作者：
McNally, Richard J.
通讯作者：
McNally, Richard J.
影响因子：
3.5
作者：
Datson, Nicole A.;Speksnijder, Niels;Lucassen, Paul J.
通讯作者：
Lucassen, Paul J.