Hypothalamic Integration of the Endocrine Signaling Related to Food Intake
Hypothalamic Integration of the Endocrine Signaling Related to Food Intake
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DOI：
10.1007/7854_2018_54
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Olszewski, Pawel K.
中科院分区：
文献类型：
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作者：
Klockars, Anica;Levine, Allen S.;Olszewski, Pawel K.
下丘脑整合的胃肠和脂肪组织来源的激素作为一个关键因素的神经内分泌控制的食物摄入。瘦素、脂联素、油酰乙醇胺、胆囊收缩素和胃饥饿素，仅举几例，与包括下丘脑群体合成促食欲素（黑素皮质素、CART、催产素）和食欲素（阿古蒂相关蛋白、神经肽Y、食欲素）的进食相关脑回路持续“串扰”。虽然这种整合的神经内分泌回路成功地确保了获得足够的能量，但它在防止过量能量摄入方面似乎并不同样有效，特别是在高热量和美味食物不断出现的致肥胖环境中。本文综述了下丘脑整合能量平衡相关的外周内分泌输入的复杂机制。我们讨论脆弱性和适应不良的神经调节过程，包括下丘脑神经元可塑性的变化，推动暴饮暴食，尽管有负面后果。
Hypothalamic integration of gastrointestinal and adipose tissue-derived hormones serves as a key element of neuroendocrine control of food intake. Leptin, adiponectin, oleoylethanolamide, cholecystokinin, and ghrelin, to name a few, are in a constant "cross talk" with the feeding-related brain circuits that encompass hypothalamic populations synthesizing anorexigens (melanocortins, CART, oxytocin) and orexigens (Agouti-related protein, neuropeptide Y, orexins). While this integrated neuroendocrine circuit successfully ensures that enough energy is acquired, it does not seem to be equally efficient in preventing excessive energy intake, especially in the obesogenic environment in which highly caloric and palatable food is constantly available. The current review presents an overview of intricate mechanisms underlying hypothalamic integration of energy balance-related peripheral endocrine input. We discuss vulnerabilities and maladaptive neuroregulatory processes, including changes in hypothalamic neuronal plasticity that propel overeating despite negative consequences.