Compensatory enlargement of the liver after treatment of hepatocellular carcinoma with carbon ion radiotherapy - Relation to prognosis and liver function
Compensatory enlargement of the liver after treatment of hepatocellular carcinoma with carbon ion radiotherapy - Relation to prognosis and liver function
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DOI：
10.1016/j.radonc.2010.03.025
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发表时间：
2010-08-01
影响因子：
5.7
通讯作者：
Tsujii, Hirohiko
中科院分区：
文献类型：
--
作者：
Imada, Hiroshi;Kato, Hirotoshi;Tsujii, Hirohiko
背景与目的 探讨1995年4月至2003年3月接受碳离子放射治疗(CIRT)治疗肝细胞癌(HCC)患者的肝脏体积变化是否影响预后和肝功能。材料与方法。 43 名局限于右肝叶的 HCC 患者被认为符合研究资格 左侧段被定义为非照射区域 在 CIRT 后 0、3、6 和 12 个月使用对比 CT 测量肝脏体积 我们检查血清白蛋白、凝血酶原活性和总胆红素水平作为肝功能储备 结果 CIRT 后，非照射区域出现明显扩大，CIRT 后 3 个月该区域体积扩大>= 50 cm(3) 是一个预后因素 较大增大组（CIRT 后 3 个月非照射区域体积增大 >= 50 cm(3)）的 5 年总生存率为 48±9%，较小增大组（如上所述，
Background and purpose To examine whether liver volume changes affect prognosis and hepatic function in patients treated with carbon ion radiotherapy (CIRT) for hepatocellular carcinoma (HCC)Material and methods Between April 1995 and March 2003. among the cases treated with CIRT. 43 patients with HCC limited to the right hepatic lobe were considered eligible for the study The left lateral segment was defined as the non-irradiated region Liver volume was measured using contrast CT at 0, 3, 6, and 12 months after CIRT We examined serum albumin, prothrombin activity, and total bilirubin level as hepatic functional reserveResults After CIRT, the non-irradiated region showed significant enlargement, and enlarged volume of this region 3 months after CIRT >= 50 cm(3) was a prognostic factor The 5-year overall survival rates were 48 9% in the larger enlargement group (enlarged volume of non-irradiated region 3 months after CIRT >= 50 cm(3)) and 29.4% in the smaller enlargement group (as above,