Macrophages and apoptotic cell clearance during pregnancy
Macrophages and apoptotic cell clearance during pregnancy
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DOI：
10.1111/j.1600-0897.2004.00156.x
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发表时间：
2004-04-01
影响因子：
3.6
通讯作者：
Mor, G
中科院分区：
文献类型：
--
作者：
Abrahams, VM;Kim, YM;Mor, G
背景技术背景：在着床过程中，细胞凋亡对于母体蜕膜的适当组织重塑和发育中胚胎的侵袭是至关重要的，然而细胞凋亡的调节对于成功妊娠也是必要的。凋亡细胞的快速和有效的去除组织巨噬细胞是一个重要的过程，它可以防止释放自身抗原，并在怀孕的情况下，父亲alloantigens.METHODS的研究：最近的研究表明，凋亡细胞清除的过程是不是一个中性的事件，而是一个积极的诱导巨噬细胞产生的抗炎细胞因子和生存因子。因此，凋亡细胞清除是必要的炎症条件，这在怀孕期间可能有致命的consequence.CONCLUSIONS：母体免疫系统的功能在植入过程中，整个怀孕期间，因此，调查的一个重要领域。本文就蜕膜巨噬细胞在妊娠期凋亡细胞清除中的作用作一综述。
BACKGROUND: During implantation, apoptosis is critical for the appropriate tissue remodeling of the maternal decidua and invasion Of the developing embryo, yet the regulation of apoptosis is also imperative for a successful pregnancy. The quick and effective removal of apoptotic cells by tissue macrophages represents an essential process, which prevents the release of self-antigens, and in the case of pregnancy, paternal alloantigens.METHODS OF STUDY: Recent studies have shown that the process of apoptotic cell clearance is not a neutral event, but rather an active one that induces macrophage production of anti-inflammatory cytokines and survival factors. Apoptotic cell clearance is, therefore, necessary for the resolution of inflammatory conditions, which during pregnancy could have lethal consequences.CONCLUSIONS: The function of the maternal immune system during implantation and throughout pregnancy is, therefore, an important area of investigation. This review will discuss the role of decidual macrophages in apoptotic cell clearance during pregnancy.