Paediatric Interstitial Lung Disease: Classification and Definitions
Paediatric Interstitial Lung Disease: Classification and Definitions
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DOI：
10.1016/j.prrv.2011.01.002
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发表时间：
2011-12-01
影响因子：
5.8
通讯作者：
Dishop, Megan K.
中科院分区：
文献类型：
--
作者：
Dishop, Megan K.
近年来，随着我们对新实体的理解以及某些组织学模式的生物学和预后意义的进展，成人和儿童间质性（弥漫性）肺疾病的分类经历了重大修订。回顾了欧洲呼吸学会儿童间质性肺病特别工作组和北美儿童间质性肺病小组的贡献，并总结了儿科弥漫性肺病的临床病理分类。还列出了该分类中选定实体的临床特征和组织学定义，特别是腺泡发育不全、先天性肺泡发育不良、肺泡毛细血管发育不良伴肺静脉错位、肺泡生长异常、肺间质糖原累积症、婴儿神经内分泌细胞增生、表面活性物质功能障碍、闭塞性细支气管炎、过敏性肺炎和免疫学疾病。在未来更统一的应用这一诊断术语将允许更有意义的比较不同的患者人群，放射学-病理学的相关性，和疾病特异性治疗策略的发展。(C)2011年由Elsevier Ltd.出版
Classifications of interstitial (diffuse) lung disease in adults and children have undergone significant revision in recent years, with advances in our understanding of new entities and the biology and prognostic significance of certain histologic patterns. The contributions of the European Respiratory Society Task Force on Interstitial Lung Disease in Children and the North American Children's Interstitial Lung Disease Group are reviewed, and a clinicopathologic classification of paediatric diffuse lung disease is summarized. Clinical characteristics and histologic definitions are also presented for selected entities within this classification, specifically, acinar dysgenesis, congenital alveolar dysplasia, alveolar capillary dysplasia with misalignment of pulmonary veins, abnormalities of alveolar growth, pulmonary interstitial glycogenosis, neuroendocrine cell hyperplasia of infancy, surfactant dysfunction disorders, obliterative bronchiolitis, hypersensitivity pneumonitis, and immunologic disorders. More uniform application of this diagnostic terminology in the future will allow more meaningful comparisons of different patient populations, radiologic-pathologic correlation, and development of disease-specific therapeutic strategies. (C) 2011 Published by Elsevier Ltd.