A direct quantitative relationship between the functional properties of human and macaque V5
A direct quantitative relationship between the functional properties of human and macaque V5
复制标题
DOI：
10.1038/76673
复制
发表时间：
2000-07-01
影响因子：
25
通讯作者：
Koch, C
中科院分区：
文献类型：
--
作者：
Rees, G;Friston, KJ;Koch, C
猴子的单个神经元记录和人类的功能磁共振成像(FMRI)测量之间的定量关系的性质，对于理解这些不同物种的实验是如何相关的至关重要，但它仍然不确定。我们使用血液氧合水平依赖(BOLD)功能磁共振成像测量了人类在接受运动视觉刺激时的大脑活动。运动信号强度(连贯性)的增加对V的反应表现出强烈的高度线性依赖关系。人类V型的这些群体反应与之前在猕猴V型中观察到的单细胞反应具有非常简单的数学关系。我们为单个神经元活性和BOLD群体反应的物种间比较提供了一个明确的定量估计。我们的数据显示了此前未知的人类Vs和其他人类运动敏感区的功能特性之间的分离，从而预测了猕猴皮质同源区域中单个神经元的特性类似的分离。
The nature of the quantitative relationship between single-neuron recordings in monkeys and functional magnetic resonance imaging (fMRI) measurements in humans is crucial to understanding how experiments in these different species are related, yet it remains undetermined. We measured brain activity in humans attending to moving visual stimuli, using blood oxygenation level-dependent (BOLD) fMRI. Responses in Vs showed a strong and highly linear dependence on increasing strength of motion signal (coherence). These population responses in human Vs had a remarkably simple mathematical relationship to previously observed single-cell responses in macaque Vs. We provided an explicit quantitative estimate for the interspecies comparison of single-neuron activity and BOLD population responses. Our data show previously unknown dissociations between the functional properties of human Vs and other human motion-sensitive areas, thus predicting similar dissociations for the properties of single neurons in homologous areas of macaque cortex.