Early response to chemotherapy as an indicator for the management of germinoma-like tumors of the pineal and/or suprasellar regions
Early response to chemotherapy as an indicator for the management of germinoma-like tumors of the pineal and/or suprasellar regions
复制标题
对化疗的早期反应作为松果体和/或鞍上区生殖细胞瘤样肿瘤治疗的指标
DOI：
10.1016/j.jocn.2013.05.014
复制
发表时间：
2014
影响因子：
2
通讯作者：
T. Tominaga
中科院分区：
文献类型：
--
作者：
R. Saito;T. Kumabe;Masayuki Kanamori;Y. Sonoda;Mika Watanabe;S. Mugikura;Shoki Takahashi;T. Tominaga
最近的进展，在诊断影像学和经验与生殖细胞瘤可能允许区分中枢神经系统生殖细胞瘤从其他肿瘤的基础上的临床信息，没有组织学验证。我们回顾性分析临床诊断的松果体和/或鞍上区生殖细胞瘤样肿瘤。这样做是为了评估我们的策略定义生殖细胞瘤兼容肿瘤的基础上，初始化疗的良好反应的有效性。分析了2001年7月至2010年10月期间接受初步治疗的34例连续生殖细胞瘤样肿瘤患者的化疗反应和生存率。评价近期患者的最小表观弥散系数（minADC）值和质子磁共振波谱（MRS）。12例经组织学证实的生殖细胞瘤患者和18例生殖细胞瘤相容性肿瘤患者在初始化疗后肿瘤体积出现早期对数下降，典型的低minADC值和典型的MRS特征，包括胆碱/肌酸比值增加，N-乙酰胆碱/肌酸比值降低和大脂质峰。这些患者有良好的无进展生存期。其他四名患者，经组织学证实的非生殖细胞瘤，化疗无反应，和一名松果体母细胞瘤患者表现出类似的minADC值和MRS特征的生殖细胞瘤患者。在松果体和/或鞍上区生殖细胞瘤样肿瘤患者中，对初始化疗的反应可用于区分生殖细胞瘤相容性肿瘤和非生殖细胞瘤。minADC和质子MRS的评价有助于生殖细胞瘤与其他肿瘤的鉴别。然而，非生殖细胞瘤的一个子集可能表现出与生殖细胞瘤相似的特征。至少在生殖细胞瘤发病率高的亚洲人群中，可以实现绕过不必要的手术干预的益处。
Recent advances in diagnostic imaging and experience with germinomas may allow for the differentiation of central nervous system germinomas from other tumors based on clinical information, without histological verification. We retrospectively analyzed clinically diagnosed germinoma-like tumors of the pineal and/or suprasellar regions. This was done to evaluate the efficacy of our strategy of defining germinoma-compatible tumors based on good responses to initial chemotherapy. The responses to chemotherapy and survival of 34 consecutive patients with germinoma-like tumors who underwent initial treatment from July 2001 to October 2010 were analyzed. The minimum apparent diffusion coefficient (minADC) value and proton magnetic resonance spectroscopy (MRS) were evaluated in recent patients. Twelve patients with histologically verified germinomas and 18 with germinoma-compatible tumors showed early logarithmic decreases in tumor volume in response to initial chemotherapy, typical low minADC values and typical MRS characteristics, including increased choline/creatine ratios, decreased N-acetylasparate/creatine ratios, and large lipid peaks. These patients had good progression-free survival. The other four patients, with histologically verified non-germinomas, showed no response to chemotherapy, and one patient with a pineoblastoma showed a similar minADC value and MRS characteristics to those of patients with germinomas. The response to initial chemotherapy can be used to distinguish germinoma-compatible tumors from non-germinoma in patients with germinoma-like tumors of the pineal and/or suprasellar regions. The evaluation of minADC and proton MRS are useful for distinguishing germinomas from other tumors. However, a subset of non-germinomas may show similar characteristics to germinomas. The benefit of bypassing unnecessary surgical intervention can be achieved, at least in Asian populations with a high incidence of germinomas.
D/L-氨基酸谱创造新美容和功能食品的可能性
DOI：
--
发表时间：
2014
期刊：
影响因子：
--
作者：
Naoki Tsunekawa;Nobuaki Higashi;Tatsuro Irimura.;Kaori Denda-Nagai and Tatsuro Irimura;入村達郎;浜瀬健司;浜瀬健司
通讯作者：
浜瀬健司
影响因子：
12.7
作者：
Louis DN;Ohgaki H;Wiestler OD;Cavenee WK;Burger PC;Jouvet A;Scheithauer BW;Kleihues P
通讯作者：
Kleihues P