Serum Cytokine Profile in Relation to the Severity of Coronary Artery Disease.
Serum Cytokine Profile in Relation to the Severity of Coronary Artery Disease.
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DOI：
10.1155/2017/4013685
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发表时间：
2017
影响因子：
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通讯作者：
Cao K
中科院分区：
文献类型：
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作者：
Min X;Lu M;Tu S;Wang X;Zhou C;Wang S;Pang S;Qian J;Ge Y;Guo Y;Xu D;Cao K
目标.探讨血清细胞因子与冠状动脉疾病（CAD）严重程度的关系。方法.共有201例因胸部不适接受冠状动脉造影的患者入组。采用xMAP多重技术测定血清IFN-γ、TNF-α、IL-2、IL-4、IL-6、IL-10、IL-9和IL-17的浓度。采用Gensini评分（GS）评估CAD严重程度。结果高GS组（GS ≥ 38.5）血清TNF-α、IL-6、IL-9、IL-10、IL-17水平显著高于低GS组（GS <38.5）。这些细胞因子与CAD的严重程度呈正相关。在调整其他相关因素后，三种血清细胞因子（IL-6、IL-9和IL-17）和两种临床危险因素（肌酐和LDL-C）被确定为CAD严重程度增加的独立预测因子。ROC曲线分析显示Logistic回归风险预测模型对冠心病严重程度有较好的预测效果。结论.血清细胞因子（IL-6、IL-9和IL-17）与临床风险因素（肌酐和LDL-C）的组合分析可能有助于评估CAD的严重程度，并可能有助于指导心绞痛患者的风险分层，特别是在初级卫生机构和导管实验室资源有限的环境中。
Objectives. To investigate the potential association of a set of serum cytokines with the severity of coronary artery disease (CAD). Methods. A total of 201 patients who underwent coronary angiography for chest discomfort were enrolled. The concentrations of serum IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-9, and IL-17 were determined by xMAP multiplex technology. The CAD severity was assessed by Gensini score (GS). Results. The serum levels of TNF-α, IL-6, IL-9, IL-10, and IL-17 were significantly higher in high GS group (GS ≥ 38.5) than those in low GS group (GS < 38.5). Positive correlations were also found between these cytokines and the severity of CAD. After adjustment for other associated factors, three serum cytokines (IL-6, IL-9, and IL-17) and two clinical risk factors (creatinine and LDL-C) were identified as the independent predictors of increased severity of CAD. ROC curve analysis revealed that the logistic regression risk prediction model had a good performance on predicting CAD severity. Conclusions. Combinatorial analysis of serum cytokines (IL-6, IL-9, and IL-17) with clinical risk factors (creatinine and LDL-C) may contribute to the evaluation of the severity of CAD and may help guide the risk stratification of angina patients, especially in primary health facilities and in the catheter lab resource-limited settings.