Evidence for and against vertical transmission for severe acute respiratory syndrome coronavirus 2
Evidence for and against vertical transmission for severe acute respiratory syndrome coronavirus 2
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DOI：
10.1016/j.ajog.2020.04.039
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发表时间：
2020-07-01
影响因子：
9.8
通讯作者：
Ville, Yves
中科院分区：
文献类型：
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作者：
Lamouroux, Audrey;Attie-Bitach, Tania;Ville, Yves
此外，严重急性呼吸系统综合征冠状病毒2型垂直传播的问题正在出现。对出现2019冠状病毒病症状的患者和新生儿进行实时鼻咽拭子、痰液和粪便聚合酶链反应，检测是否存在严重急性呼吸综合征冠状病毒2。此外，对阴道拭子、羊水、胎盘、脐带血、新生儿血或母乳进行实时聚合酶链反应检测严重急性呼吸综合征冠状病毒2型的结果也不明显。在表现出2019年冠状病毒病症状的成年患者中，有1%存在病毒血症。在这里，我们回顾了2020年2月10日至2020年4月4日期间发表的12篇文章，这些文章报道了68例分娩和71例妊娠晚期孕产妇感染的新生儿。为了确定感染是先天性的还是围产期的，我们考虑了围产期暴露、分娩方式以及从分娩到诊断新生儿感染的时间间隔。新生儿感染严重急性呼吸综合征冠状病毒2型通常无症状。在4例病例中，在生命后48小时内进行了严重急性呼吸综合征冠状病毒2型感染诊断测试。此外，还讨论了脐带和新生儿血液中实时聚合酶链反应的检出率以及免疫球蛋白M和免疫球蛋白G抗体水平与胎儿不成熟和新生儿免疫系统的关系。
COVID-19 can severely affect pregnant women Furthermore, issues regarding vertical transmission of severe acute respiratory syndrome coronavirus 2 are emerging. In patients and neonates who are showing symptoms of coronavirus disease 2019, real-time polymerase chain reaction of nasal and throat swabs, sputum, and feces is performed to detect the presence of severe acute respiratory syndrome coronavirus 2. In addition, real-time polymerase chain reaction of vaginal swabs, amniotic fluid, placenta, cord blood, neonatal blood, or breast milk for the detection of severe acute respiratory syndrome coronavirus 2 did not show substantial results. Viremia was present in 1% of adult patients who were showing symptoms of coronavirus disease 2019. Here, we reviewed 12 articles published between Feb. 10, 2020, and April 4, 2020, that reported on 68 deliveries and 71 neonates with maternal infection in the third trimester of pregnancy. To determine whether infection occurred congenitally or perinatally, perinatal exposure, mode of delivery, and time interval from delivery to the diagnosis of neonatal infection were considered. Neonates with severe acute respiratory syndrome coronavirus 2 infection are usually asymptomatic. In 4 cases, a diagnostic test for severe acute respiratory syndrome coronavirus 2 infection was performed within 48 hours of life. Furthermore, detection rates of real-time polymerase chain reaction and the interpretation of immunoglobulin M and immunoglobulin G antibodies levels in cord and neonatal blood were discussed in relation with the immaturity of the fetal and neonatal immune system.