Relationship between handgrip strength and albuminuria in community-dwelling elderly Japanese subjects: the Shika Study
Relationship between handgrip strength and albuminuria in community-dwelling elderly Japanese subjects: the Shika Study
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DOI：
10.1080/1354750x.2020.1819418
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发表时间：
2020-09
期刊：
影响因子：
2.6
通讯作者：
Akinori Hara;H. Tsujiguchi;Keita Suzuki;Y. Tao;Haruki Nakamura;Tomoko Kasahara;T. T. Nguyen-T.;Sakae Miyagi;Yukari Shimizu;T. Kannon;Atsushi Tajima;T. Wada;T. Takamura;Hiroyuki Nakamura
中科院分区：
文献类型：
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作者：
Akinori Hara;H. Tsujiguchi;Keita Suzuki;Y. Tao;Haruki Nakamura;Tomoko Kasahara;T. T. Nguyen-T.;Sakae Miyagi;Yukari Shimizu;T. Kannon;Atsushi Tajima;T. Wada;T. Takamura;Hiroyuki Nakamura
摘要目的本研究旨在调查日本一般人群中按性别和年龄划分的握力（HGS）与蛋白尿之间的关系。方法这项基于人群的横断面研究招募了916名年龄≥40岁的日本参与者。测定白蛋白尿，并表示为尿白蛋白与肌酐比值（UACR）。使用标准化方案测量生化、营养和人体测量概况以及HGS。结果432例（47%）男性，484例女性，平均年龄分别为62 ± 11岁和63 ± 11岁。在两种性别的受试者中，HGS、年龄较大、高体重指数、存在高血压或糖尿病以及估计的肾小球滤过率降低与对数转换的UACR相关。多变量线性回归分析显示，在≥65岁的男性[β系数-0.43; 95%置信区间（CI）-0.73，-0.13]和女性（β系数-0.50; 95% CI-0.90，-0.10）中，HGS与log UACR独立相关;然而，在年轻参与者中未观察到类似的相关性。结论日本老年男性和女性中低HGS与蛋白尿相关。
Abstract Purpose This study aimed to investigate the association between handgrip strength (HGS) and albuminuria in the general population of Japan as per sex and age. Methods This population-based, cross-sectional study enrolled 916 Japanese participants aged ≥40 years. Albuminuria was measured and expressed as the urinary albumin-to-creatinine ratio (UACR). Biochemical, nutritional, and anthropometric profiles as well as HGS were measured using standardised protocols. Results Four hundred and thirty-two (47%) of the study participants were men, and 484 were women, with respective mean ages of 62 ± 11 years and 63 ± 11 years. HGS, older age, high body mass index, presence of hypertension or diabetes, and a decreased estimated glomerular filtration rate were correlated with the log-transformed UACR in subjects of both sexes. Multivariate linear regression analysis showed that HGS was independently associated with the log UACR in both, men [beta coefficient −0.43; 95% confidence interval (CI) −0.73, −0.13] and women (beta coefficient −0.50; 95% CI −0.90, −0.10) aged ≥65 years; however, a similar association was not observed in younger participants. Conclusion Low HGS was associated with albuminuria in older men and women in Japan.