Multiple timescales of sensory-evidence accumulation across the dorsal cortex.
Multiple timescales of sensory-evidence accumulation across the dorsal cortex.
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DOI：
10.7554/elife.70263
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发表时间：
2022-06-16
期刊：
影响因子：
7.7
通讯作者：
Brody, Carlos D.
中科院分区：
文献类型：
--
作者：
Pinto, Lucas;Tank, David W.;Brody, Carlos D.
皮质区似乎形成了内在时间尺度的层次结构，但这种组织与认知行为的相关性仍然未知。特别是，需要随着时间的推移逐渐积累感官证据的决定在这个等级制度中招募了广泛的领域。在这里，我们测试的假设，这种招聘是与这些广泛的领域的内在整合时标。我们训练小鼠在虚拟现实中导航时在几秒钟内积累证据，并在不同的短暂试验时期内光遗传学地沉默了许多皮层区域的活动。我们发现所有测试区域的失活影响了证据累积计算。具体来说，我们观察到不同的变化中发生的感觉证据的权重沉默期间和之前，这样的额叶失活导致更强的赤字在较长的时间尺度上比后皮质的。额叶区域的一个子集的失活也导致了超出证据积累的行为过程的中度影响。此外，大规模的皮层Ca 2+活动在任务执行过程中显示不同的时间整合窗口。我们的研究结果表明，内在的时间尺度层次分布的皮质区是证据积累机制的一个重要组成部分。
Cortical areas seem to form a hierarchy of intrinsic timescales, but the relevance of this organization for cognitive behavior remains unknown. In particular, decisions requiring the gradual accrual of sensory evidence over time recruit widespread areas across this hierarchy. Here, we tested the hypothesis that this recruitment is related to the intrinsic integration timescales of these widespread areas. We trained mice to accumulate evidence over seconds while navigating in virtual reality and optogenetically silenced the activity of many cortical areas during different brief trial epochs. We found that the inactivation of all tested areas affected the evidence-accumulation computation. Specifically, we observed distinct changes in the weighting of sensory evidence occurring during and before silencing, such that frontal inactivations led to stronger deficits on long timescales than posterior cortical ones. Inactivation of a subset of frontal areas also led to moderate effects on behavioral processes beyond evidence accumulation. Moreover, large-scale cortical Ca2+ activity during task performance displayed different temporal integration windows. Our findings suggest that the intrinsic timescale hierarchy of distributed cortical areas is an important component of evidence-accumulation mechanisms.