Shedding light on integrative GA signaling.
Shedding light on integrative GA signaling.
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DOI：
10.1016/j.pbi.2014.06.010
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发表时间：
2014-10
影响因子：
9.5
通讯作者：
Hao Xu;Qian Liu;Tao Yao;Xiangdong Fu
中科院分区：
文献类型：
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作者：
Hao Xu;Qian Liu;Tao Yao;Xiangdong Fu
GA-GID 1-DELLA调控模块在GA信号转导中起重要作用。DELLA蛋白通过蛋白质-蛋白质相互作用调节一系列激素和环境信号活动。DELLA-PFD复合物调节GA介导的CMT组织和细胞扩增。一条非DELLA依赖的途径参与GA反应的调控。赤霉素（GA）调节与植物生长发育相关的多种过程。DELLA蛋白充当GA信号传导的阻遏物，并且被GA去稳定化。尽管已知GA信号转导整合了各种内源和环境信号，但它们调节植物生长和发育的分子基础现在才开始被理解。目前的建议是，DELLA蛋白作为一种可能的植物生长的定量调节剂，通过蛋白质-蛋白质相互作用整合多种环境和激素信号来实现。本文综述了最近阐述的去阻遏模型提出来描述GA的反应，并侧重于整合网络，认为调节植物的生长，发育和适应波动的环境。
HighlightsThe GA–GID1–DELLA regulatory module plays an important role in GA signaling.DELLA proteins modulate a range of hormonal and environmental signaling activities through protein–protein interactions.The DELLA–PFD complex modulates GA-mediated CMT organization and cell expansion.A DELLA-independent pathway is involved in the regulation of GA responses.Gibberellic acid (GA) regulates a diversity of processes associated with plant growth and development. The DELLA proteins act as repressors of GA signaling, and are destabilized by GA. Although it is known that GA signaling integrates various endogenous and environmental signals, the molecular basis of their modulation of plant growth and development is only now beginning to be understood. The current suggestion is that the DELLA proteins act as one possible quantitative modulator of plant growth, achieved by integrating multiple environmental and hormonal signals via protein–protein interactions. This review discusses recent elaborations of the de-repression model proposed to describe the GA response, and focuses on integrative networks thought to regulate plant growth, development and the adaptation to a fluctuating environment.