Goldbeter-Koshland model for open signaling cascades: a mathematical study
Goldbeter-Koshland model for open signaling cascades: a mathematical study
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DOI：
10.1007/s00285-009-0322-3
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发表时间：
2010-12-01
影响因子：
1.9
通讯作者：
Srividhya, Jeyaraman
中科院分区：
文献类型：
--
作者：
Li, Yongfeng;Srividhya, Jeyaraman
提出了一个改进的Goldbeter-Koshland（GK）模型来研究具有前向激活的开放信号级联反应。三个不同的制度有关的超灵敏度明确界定。当叶栅足够长时，下游循环中的稳态表现出极限行为。同时，在没有任何反馈电路的情况下，在超灵敏度前的状态下揭示了一种类似时间开关的行为。对这一现象进行了详细的分析。
A modified Goldbeter-Koshland (GK) type model is proposed to study the open signaling cascade with forward activation. Three different regimes related to the ultrasensitivity are clearly defined. When the cascade is sufficiently long, the steady states in the downstream cycles exhibit a limiting behavior. Meanwhile, a temporal switch-like behavior is revealed in the pre-ultrasensitivity regime without any feedback circuitry. A detailed analysis of this phenomenon is provided.