Substantia Nigra Free Water Increases Longitudinally in Parkinson Disease.
Substantia Nigra Free Water Increases Longitudinally in Parkinson Disease.
复制标题
帕金森氏病的底底尼格拉无水纵向增加。
DOI：
10.3174/ajnr.a5545
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发表时间：
2018-03
期刊：
影响因子：
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通讯作者：
Zivadinov R
中科院分区：
文献类型：
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作者：
Guttuso T Jr;Bergsland N;Hagemeier J;Lichter DG;Pasternak O;Zivadinov R
在早期特发性帕金森病(IPD)患者中，从双张量扩散磁共振成像模型中获得的黑质后部(PSN)的游离水(FW)在1年和4年期间显著高于健康对照组(HC)，提示PSN FW可能是IPD进展的生物标志物。由于已知的IPD后侧至前侧SN退行性变，我们评估了晚期IPD患者后侧(P)和前侧(A)SN的FW纵向变化，并与年龄匹配的HC进行比较。19名IPD和19名年龄匹配的HC受试者在基线和大约3年后接受相同的3T-MRI检查。基线平均IPD持续时间为7.1年。ASN和PSN FW在基线时都显示出显著的组间差异(p<；0.001和p=0.014，IPD与HC相比)；然而，只有ASN FW显示出显著的纵向组x时间交互作用增加(p=0.021，IPD与HC)。在ASN或PSN中，常规弥散张量成像(DTI)或经FW校正的DTI评估的纵向组x时间相互作用没有显著差异。这项研究的结果提供了进一步的证据，支持SN FW作为IPD中有前景的疾病进展生物标记物，如果在未来的临床试验中使用，可能有助于识别疾病修改疗法。我们新发现的ASN而不是PSN FW的纵向增加可能是由于我们的队列比以前研究的队列的病程要长得多，以及已知的IPD中随着时间的推移发生的从后到前的SN变性。
Free-water (FW) in the posterior substantia nigra (pSN) obtained from a bi-tensor diffusion MRI model has been shown to significantly increase over 1 and 4 years in early-stage Idiopathic Parkinson’s disease (IPD) compared to healthy controls (HC) suggesting that pSN FW may be an IPD progression biomarker. Due to the known temporal posterior-to-anterior SN degeneration in IPD, we assessed for longitudinal changes in FW in both the posterior (p) and anterior (a) SN in later-stage IPD and age-matched HC for comparison. 19 IPD and 19 age-matched HC subjects were assessed on the same 3T-MRI at Baseline and after approximately 3-years. Baseline mean IPD duration was 7.1 years. Both aSN and pSN FW showed significant intergroup differences at Baseline (p<0.001 and p=0.014, respectively, IPD vs. HC); however, only aSN FW showed significant longitudinal group x time interaction increases (p=0.021, IPD vs. HC). There were no significant longitudinal group x time interaction differences found for conventional diffusion tensor imaging (DTI) or FW-corrected DTI assessments in either the aSN or pSN. Results from this study provide further evidence supporting SN FW as a promising disease progression biomarker in IPD that may help to identify disease-modifying therapies if used in future clinical trials. Our novel finding of longitudinal increases in aSN and not pSN FW is potentially a result of the much longer disease duration of our cohort compared to previously studied cohorts and the known posterior-to-anterior SN degeneration that occurs over time in IPD.