BREFELDIN A BLOCKS PROTEIN GLYCOSYLATION AND RNA REPLICATION OF VESICULAR STOMATITIS-VIRUS
BREFELDIN A BLOCKS PROTEIN GLYCOSYLATION AND RNA REPLICATION OF VESICULAR STOMATITIS-VIRUS
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DOI：
10.1016/0014-5793(93)80863-p
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发表时间：
1993-12-28
期刊：
影响因子：
3.5
通讯作者：
CARRASCO, L
中科院分区：
文献类型：
--
作者：
IRURZUN, A;PEREZ, L;CARRASCO, L
布雷菲德菌素A是一种大环内酯类抗生素，可干扰膜运输并阻断包括水泡性口炎病毒（VSV）在内的几种动物病毒的生长。布雷菲德菌素A对VSV的抑制在生长周期中至少发生在两个不同的步骤：VSV G蛋白的糖基化和病毒基因组的复制。我们的研究结果表明，干扰膜交通导致不仅抑制病毒蛋白糖基化，但也阻断病毒基因组复制在几个细胞质RNA的病毒。
Brefeldin A is a macrolide antibiotic that interferes with membrane traffic and blocks the growth of several animal viruses including vesicular stomatitis virus (VSV). The inhibition of VSV by brefeldin A takes place at least at two different steps during the growth cycle: the glycosylation of VSV G protein and the replication of viral genomes. Our results indicate that interference with membrane traffic leads not only to inhibition of viral protein glycosylation, but also to the blockade of virus genome replication in several cytoplasmic RNA-containing viruses.