The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity.
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity.
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DOI：
10.1007/978-3-642-21631-2_7
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发表时间：
2011
影响因子：
--
通讯作者：
Imai, Shin
中科院分区：
文献类型：
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作者：
Satoh, Akiko;Stein, Liana;Imai, Shin
自从10年前发现sirtuins以来，人们对NAD依赖性脱乙酰酶家族的兴趣激增，产生了多条证据，表明sirtuins是进化上保守的寿命调节因子。在哺乳动物中，已经确定sirtuins调节对代谢和应激的生理反应，这是影响衰老过程的两个关键因素。对sirtuins，代谢和衰老之间的密切联系的进一步研究表明，SIRT1的激活可以作为预防和治疗多种年龄相关疾病的措施，包括2型糖尿病和阿尔茨海默病。SIRT1的激活不仅可以预防与年龄相关的疾病，还可以延长健康寿命，甚至寿命。Sirtuin激活化合物和NAD中间体是实现这些难以捉摸的目标的两种有前途的方法。
Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as evolutionarily conserved regulators of lifespan. In mammals, it has been established that sirtuins regulate physiological responses to metabolism and stress, two key factors that affect the process of aging. Further investigation into the intimate connection among sirtuins, metabolism, and aging has implicated the activation of SIRT1 as both preventative and therapeutic measures against multiple age-associated disorders including type 2 diabetes and Alzheimer’s disease. SIRT1 activation has clear potential to not only prevent age-associated diseases but also to extend healthspan and perhaps lifespan. Sirtuin activating compounds and NAD intermediates are two promising ways to achieve these elusive goals.