Electrochemical studies of ceria as electrode material for sensing and biosensing applications
Electrochemical studies of ceria as electrode material for sensing and biosensing applications
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DOI：
10.1149/1.2936178
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发表时间：
2008-01-01
影响因子：
3.9
通讯作者：
Andreescu, Silvana
中科院分区：
文献类型：
--
作者：
Ispas, Cristina;Njagi, John;Andreescu, Silvana
这项工作介绍了作为电极材料的二氧化铈的电化学研究，并描述了探索该材料独特的催化和氧化还原特性的新可能性，以开发用于测定H2O2的简单无酶传感器和用于生物传感器制造。采用循环伏安法首次研究了氧化铈在碱性和中性条件下对过氧化氢氧化还原的电催化活性。提出了一种涉及不同氧化态和不同反应种类的反应机理。该传感器可快速、灵敏、准确地测量H2O2，响应时间小于10 s，检出限为98 nM，灵敏度为0.24 μ a μ M-1。该材料为葡萄糖氧化酶的固定化提供了生物相容性基质，并促进了其活性中心与电极表面之间的直接电子转移，电子转移速率常数为18.3 s(-1)，表面覆盖率为1.4 × 10(-11) mol/cm(2)。本研究介绍了二氧化铈作为传感和生物传感电极材料的应用。(C) 2008电化学学会。
This work presents electrochemical studies of ceria as an electrode material and describes new possibilities of exploring the unique catalytic and redox properties of this material for the development of a simple enzymeless sensor for the determination of H2O2 and for biosensor manufacturing. The investigation of the electrocatalytic activity of ceria toward the oxidation and reduction of hydrogen peroxide was first carried out using cyclic voltammetry in alkaline and neutral conditions. A possible reaction mechanism was suggested involving different cerium oxidation states and reactive species. The ceria-based sensor resulted in rapid, sensitive, and accurate measurement of H2O2, with a response time of less than 10 s, a detection limit of 98 nM, and a sensitivity of 0.24 mu A mu M-1. This material provided a biocompatible matrix for the immobilization of glucose oxidase and facilitated direct electron transfer between its active center and the electrode surface, with an electron-transfer rate constant of 18.3 s(-1) and a surface coverage of 1.4x10(-11) mol/cm(2). This study introduces ceria as electrode material for sensing and biosensing applications. (C) 2008 The Electrochemical Society.