Lateralized organization of the cerebellum in a silent verbal fluency task: a functional magnetic resonance imaging study in healthy volunteers
Lateralized organization of the cerebellum in a silent verbal fluency task: a functional magnetic resonance imaging study in healthy volunteers
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DOI：
10.1016/s0304-3940(01)02566-6
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发表时间：
2002-02-15
影响因子：
2.5
通讯作者：
Braus, DF
中科院分区：
文献类型：
--
作者：
Hubrich-Ungureanu, P;Kaemmerer, N;Braus, DF
在功能上，小脑不仅参与运动控制，而且被认为影响包括语言在内的高级认知功能。解剖学数据表明，小脑和高级皮质联合区之间存在交叉的相互联系。在下面的研究中，一个左利手和一个右利手的女性志愿者接受了功能磁共振成像在一个传统的块设计。在扫描仪内执行无声的语言流畅性任务后，检测到激活区域。在右撇子志愿者中，我们发现左额顶叶皮层和右小脑半球被激活，而在左撇子志愿者中，激活出现在右额顶叶颞叶皮层和左小脑半球。这些初步结果表明，小脑激活是对侧的额叶皮层激活，即使在不同的语言优势的条件下。它们为小脑的偏侧组织交叉到大脑半球以支持更高的认知功能的假设提供了证据。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Functionally, the cerebellum is not only involved in motor control but is also thought to influence higher cognitive function including language. Anatomical data would suggest crossed reciprocal connections between the cerebellum and higher order cortical association areas. In the following study, one left- and one right-handed female volunteer underwent functional magnetic resonance imaging in a conventional block design. Regions of activation were detected after performance of a silent verbal fluency task inside the scanner. In the right-handed volunteer we found an activation of the left fronto-parietal cortex and the right cerebellar hemisphere, while in the left-handed volunteer the activation was seen in the right fronto-parieto-temporal cortex and the left cerebellar hemisphere. These initial results demonstrate that cerebellar activation is contralateral to the activation of the frontal cortex even under conditions of different language dominance. They provide evidence for the hypothesis of a lateralized organization of the cerebellum crossed to the cerebral hemispheres in supporting higher cognitive function. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.