Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation.
Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation.
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免疫抑制药物允许的供体细胞嵌合：器官移植的新观点。
DOI：
10.1016/0165-6147(93)90212-3
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发表时间：
1993
影响因子：
13.8
通讯作者：
Ricordi,C
中科院分区：
文献类型：
--
作者：
Starzl,TE;Demetris,AJ;Murase,N;Thomson,AW;Trucco,M;Ricordi,C
器官移植中的一种思路认为，免疫抑制药物可以通过允许以前未被认识的细胞迁移和微生物二聚体的常见机制发生、持续，并在某些情况下变得不依赖于药物来诱导耐受。人们已经认识到，不同器官对细胞排斥的敏感性存在一定范围，并且这些器官诱导供体特异性非反应性的可变能力反映了它们的迁移性白细胞的相对含量。在此，Thomas Starzl 及其同事讨论了这种二聚现象可以解释移植免疫学的许多谜团。人们越来越多地根据破坏同种异体激活 T 细胞反应的分子位点来描述各种免疫抑制剂对器官排斥的预防。然而，最近的证据表明，排斥反应的控制以及最终的移植物接受取决于 这些药物对共同宿主——移植物白细胞的许可作用； granon 在成功的病例中导致受体和移植物中出现混合的长期微嵌合现象 3（图 1）。
One line of thought in organ transplantation feels that immunosuppressive drugs can lead to tolerance induction by allowing a previously unrecognized common mechanism of cell migration and microcbimerism to occur, persist, and in some cases, become drug independent. It has been recognized that there is a spectrum of susceptibility of different organs to cellular rejection and that the variable ability of these organs to induce donorspecific nonreactivity reflects their comparative content of migratory leukocytes. Here, Thomas Starzl and colleagues discuss bow many of the enigmas of transplantation immunology can be explained by this cbimerism.The prevention of organ rejection by various immunosuppressive agents has been described increasingly in terms of tbe molecular site of disruption of the alloactivated T-cell response~, 2. Recent evidence, however, suggests that the control of rejection and, ultimately, graft acceptance depend on a permissive effect of these drugs on a mutual host--graft leukocyte rn; granon that leads in successful cases to mixed, long-term microchimerism in the recipient as well as the transplant 3 (Fig. 1).