Evaluation of the PHQ-2 as a Brief Screen for Detecting Major Depression Among Adolescents
Evaluation of the PHQ-2 as a Brief Screen for Detecting Major Depression Among Adolescents
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DOI：
10.1542/peds.2009-2712
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发表时间：
2010-05-01
期刊：
影响因子：
8
通讯作者：
Katon, Wayne
中科院分区：
文献类型：
--
作者：
Richardson, Laura P.;Rockhill, Carol;Katon, Wayne
目的：检验患者健康问卷 2 (PHQ-2)（2 项抑郁症筛查量表）在青少年中的有效性。 方法：在完成简短的抑郁症筛查后，499 名参加综合医疗保健系统的青少年（13-17 岁）被邀请参加全面评估，包括较长的抑郁症筛查量表（患者健康问卷 9 项抑郁症筛查）和结构化心理健康访谈（儿童诊断访谈时间表）。百分之八十九 (n = 444) 完成了评估。通过检查 PHQ-2 与抑郁症和功能障碍的其他测量值之间的关联来测试标准有效性和结构有效性。 结果：PHQ-2 评分 >= 3 时，对于检测符合《精神疾病诊断与统计手册》第四版、儿童诊断访谈表中重度抑郁症标准的青少年，敏感性为 74%，特异性为 75%；对于检测符合以下标准的青少年，敏感性为 96%，特异性为 82%。患者健康问卷 9 项抑郁症屏幕上可能出现重度抑郁症。在接受者操作特征分析中，PHQ-2 的曲线下面积为 0.84（95% 置信区间：0.75-0.92），切点 3 是在不损失检测重度抑郁症特异性的情况下最大化灵敏度的最佳选择。与得分为 3 的青少年相比，PHQ-2 评分 >= 3 的青少年的功能障碍评分显着更高，并且家长报告的内化问题评分也显着更高。
OBJECTIVE: To examine the validity of the Patient Health Questionnaire 2 (PHQ-2), a 2-item depression-screening scale, among adolescents.METHODS: After completing a brief depression screen, 499 youth (aged 13-17 years) who were enrolled in an integrated health care system were invited to participate in a full assessment, including a longer depression-screening scale (Patient Health Questionnaire 9-item depression screen) and a structured mental health interview (Diagnostic Interview Schedule for Children). Eighty-nine percent (n = 444) completed the assessment. Criterion validity and construct validity were tested by examining associations between the PHQ-2 and other measures of depression and functional impairment.RESULTS: A PHQ-2 score of >= 3 had a sensitivity of 74% and specificity of 75% for detecting youth who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for major depression on the Diagnostic Interview Schedule for Children and a sensitivity of 96% and specificity of 82% for detecting youth who met criteria for probable major depression on the Patient Health Questionnaire 9-item depression screen. On receiver operating characteristic analysis, the PHQ-2 had an area under the curve of 0.84 (95% confidence interval: 0.75-0.92), and a cut point of 3 was optimal for maximizing sensitivity without loss of specificity for detecting major depression. Youth with a PHQ-2 score of >= 3 had significantly higher functional-impairment scores and significantly higher scores for parent-reported internalizing problems than youth with scores of