New Insights into Tumor-Infiltrating B Lymphocytes in Breast Cancer: Clinical Impacts and Regulatory Mechanisms.
New Insights into Tumor-Infiltrating B Lymphocytes in Breast Cancer: Clinical Impacts and Regulatory Mechanisms.
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乳腺癌肿瘤浸润 B 淋巴细胞的新见解：临床影响和调节机制
DOI：
10.3389/fimmu.2018.00470
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发表时间：
2018
影响因子：
7.3
通讯作者：
Ren X
中科院分区：
文献类型：
--
作者：
Shen M;Wang J;Ren X
目前，肿瘤浸润性B淋巴细胞已被认为是乳腺癌（BC）的新标志。该功能在乳腺癌的预测和预后中有积极意义、消极意义或无意义。此外，B细胞浸润通过产生抗体和白细胞介素-10来调节肿瘤过程。还记录了与其他淋巴细胞和程序性死亡-1/PD-1配体轴的相互作用。这些调控机制最终将被纳入诊断和治疗算法，从而指导临床治疗。在这篇综述中，我们对肿瘤浸润B细胞的临床影响和调节机制提出了新的见解，这预示着BC治疗中免疫肿瘤学的新时代。
Currently, tumor-infiltrating B lymphocytes have been recognized as a new hallmark of breast cancer (BC). The function seems to be controversial, either with positive, negative, or no significance in BC’s prediction and prognosis. Moreover, B-cell infiltrates regulate tumor process through productions of antibodies and interleukin-10. The interactions with other lymphocytes and programmed death-1/PD-1 ligand axis are also documented. The regulatory mechanisms will eventually be incorporated into diagnostic and therapeutic algorithms, thus give guide to clinical treatment. In this review, we give new insights into clinical impacts and regulatory mechanisms of tumor-infiltrating B cells, which heralds a new era in immuno-oncology in BC treatment.