Biotype traits and antibiotic susceptibility of Vibrio cholerae serogroup O1 before, during and after the emergence of the O139 serogroup
Biotype traits and antibiotic susceptibility of Vibrio cholerae serogroup O1 before, during and after the emergence of the O139 serogroup
复制标题
O139血清群出现之前、期间和之后霍乱弧菌O1血清群的生物型特征和抗生素敏感性
作者：
Ashis Mukhopadhyay;S. Garg;G. Nair;S. Kar;R. K. Ghosh;S. Pajni;Alip Ghosh;Toshio Shimada;Tae Takeda;Y. Takeda
对在不同时间分离的69株霍乱弧菌01进行了分析，以研究在O139血清群出现之前、期间和之后分离的01株之间是否存在任何差异。在检测的69 01株菌株中，68株属于Ogawa血清型，1株属于Inaba血清型。除一株外，所有其他霍乱弧菌01株均属于eltor生物型。在O139血清群出现之前分离的单一O1菌株不能被归类为eltor或经典生物型，因为它对经典和eltor特异性噬菌体都具有抗性。不同时期分离的霍乱弧菌O1对抗生素的敏感性存在明显差异。此外，与O139血清群出现之前分离的O1菌株相比，在加尔各答O139血清群流行后分离的霍乱弧菌菌株显示出对多种药物具有抗性的扩大的R型。从这项研究中可以清楚地看出，霍乱弧菌的遗传元件具有很大的流动性，这需要持续监测以跟上霍乱病原体的变化特征。
Summary Sixty-nine strains of Vibrio cholerae 01 isolated at different times were analysed to investigate if there were any differences among the 01 strains isolated before, during and after the advent of the O139 serogroup. Of the 69 01 strains examined, 68 belonged to the Ogawa serotype while one belonged to the Inaba serotype. With the exception of one strain all other strains of V. cholerae 01 belonged to the eltor biotype. A single O1 strain isolated before the emergence of the O139 serogroup could not be classified as either eltor or classical biotype because it was resistant to both classical and eltor specific bacteriophages. Marked variations in the susceptibility to antibiotics of V. cholerae O1 isolated during the different periods were observed. In addition, strains of V. cholerae isolated after the epidemic of serogroup O139 in Calcutta showed an expanding R-type with resistance to a variety of drugs as compared to the 01 strains isolated before the advent of the O139 serogroup. From this study, it is clear that there is a substantial mobility in genetic elements of V. cholerae Ol which necessitates a continuous monitoring to keep abreast of the changing traits of the etiologic agent of cholera.