Wnt3a: functions and implications in cancer.
Wnt3a: functions and implications in cancer.
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Wnt3a：在癌症中的功能和影响。
DOI：
10.1186/s40880-015-0052-4
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发表时间：
2015-09-14
影响因子：
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通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
He S;Lu Y;Liu X;Huang X;Keller ET;Qian CN;Zhang J
Wnt 3a是Wnt家族成员之一，在调节多效细胞功能中起关键作用，包括自我更新、增殖、分化和运动。越来越多的证据表明，Wnt3a通过典型的Wnt信号通路促进或抑制肿瘤进展，这取决于癌症类型。此外，Wnt3a信号传导的作用可以被多种蛋白质或化学物质抑制。在此，我们总结了Wnt3a作为癌症重要治疗靶点的最新研究结果。
Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer.