Metabolic Phenotype and Risk of Colorectal Cancer in Normal-Weight Postmenopausal Women.
Metabolic Phenotype and Risk of Colorectal Cancer in Normal-Weight Postmenopausal Women.
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DOI：
10.1158/1055-9965.epi-16-0761
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Luo J
中科院分区：
文献类型：
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作者：
Liang X;Margolis KL;Hendryx M;Rohan TE;Groessl EJ;Thomson CA;Kroenke CH;Simon MS;Lane D;Stefanick M;Luo J
在正常体重的成年人中，代谢不健康表型的患病率为30%，很少有研究探讨代谢表型与正常体重个体的结直肠癌发病率之间的关系。我们的目的是比较具有代谢健康表型和代谢不健康表型特征的绝经后正常体重女性患结直肠癌的风险。使用了一个大型预期队列，即妇女健康倡议(WHI)。分析样本包括5068名绝经后妇女，体重指数为18.5-25公斤/平方米。代谢表型的定义使用成人治疗小组III(ATP-III)的定义，不包括腰围；因此，四种成分(甘油三酯升高、高密度脂蛋白-C降低、血压升高和空腹血糖升高)中有一种或没有一种的女性被归类为代谢健康。多变量Cox比例风险回归被用来估计代谢表型与结直肠癌风险之间的关系的调整风险比。在体重正常的女性中，与代谢健康的女性相比，代谢不健康的女性患结直肠癌的风险更高(HR：1.49，95%CI：1.02-2.18)。在正常体重的女性中，代谢不健康的表型与结直肠癌的高风险相关。正常体重的女性仍应接受代谢健康评估，并采取适当措施降低患结直肠癌的风险。
The prevalence of metabolically unhealthy phenotype in normal-weight adults is 30%, and few studies have explored the association between metabolic phenotype and colorectal cancer incidence in normal-weight individuals. Our aim was to compare the risk of colorectal cancer in normal-weight postmenopausal women who were characterized by either the metabolically healthy phenotype or the metabolically unhealthy phenotype. A large prospective cohort, the Women’s Health Initiative (WHI), was used. The analytical sample included 5,068 postmenopausal women with BMI 18.5–<25 kg/m2. Metabolic phenotype was defined using the Adult Treatment Panel-III (ATP-III) definition, excluding waist circumference; therefore, women with one or none of the four components (elevated triglycerides, low HDL-C, elevated blood pressure, and elevated fasting glucose) were classified as metabolically healthy. Multivariable Cox proportional hazards regression was used to estimate adjusted hazard ratios for the association between metabolic phenotype and risk of colorectal cancer. Among normal-weight women, those who were metabolically unhealthy had higher risks of colorectal cancer (HR: 1.49, 95% CI: 1.02–2.18) compared to those who were metabolically healthy. A metabolically unhealthy phenotype was associated with higher risk of colorectal cancer among normal-weight women. Normal-weight women should still be evaluated for metabolic health and appropriate steps taken to reduce their risk of colorectal cancer.