11C-Acetate PET imaging for renal cell carcinoma
11C-Acetate PET imaging for renal cell carcinoma
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DOI：
10.1007/s00259-008-0981-0
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发表时间：
2009-03-01
影响因子：
9.1
通讯作者：
Yokoyama, Osamu
中科院分区：
文献类型：
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作者：
Oyama, Nobuyuki;Okazawa, Hidehiko;Yokoyama, Osamu
本研究对20例疑似肾肿瘤患者（其中1例有3处肾肿瘤）进行了正电子发射断层扫描（PET），观察了CT显像对肾细胞癌的诊断价值。总共评价了22处肾脏病变。给予350 MBq（10 mCi）AC后，获得全身PET图像。根据这些PET结果，将肾脏病变评分为阳性或阴性。PET检查结果与CT检查结果及术后组织学诊断相对照，18例患者中20例诊断为肾癌。其余2例患者的病变被诊断为无恶性组织的复杂囊肿。在20例肾细胞癌中。14例（70%）AC PET阳性，6例阴性。2例合并囊肿的患者AC PET检查阴性。20例肾细胞癌中透明细胞癌19例，乳头状细胞癌1例。乳头状细胞癌显示AC高摄取，肾细胞癌显示AC明显摄取。这些初步数据表明，AC是一个可能的PET示踪剂检测肾癌。
In this study, we investigated the effectiveness of positron emission tomography (PET) with C-11-acetate (AC) for evaluation of renal cell carcinoma.Enrolled in the study were 20 patients with suspected renal tumour, one of whom had three renal lesions. In all, 22 renal lesions were evaluated. Following administration of 350 MBq (10 mCi) of AC, whole-body PET images were obtained. Based on these PET findings, kidney lesions were scored as positive or negative. The PET results were correlated with the CT findings and histological diagnosis after surgery.In 18 patients, 20 tumours were diagnosed as renal cell carcinoma. Lesions in the remaining two patients were diagnosed as complicated cyst without malignant tissue. Of the 20 renal cell carcinomas. 14 (70%) showed positive AC PET findings; 6 were negative. The two patients with complicated cyst had negative AC PET findings. Of the 20 renal cell carcinomas, 19 were clear-cell carcinoma and 1 was a papillary cell carcinoma. This papillary cell carcinoma showed high AC uptake.AC demonstrates marked uptake in renal cell carcinoma. These preliminary data show that AC is a possible PET tracer for detection of renal cancer.